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首页> 外文期刊>Hong Kong Journal of Paediatrics >Frequency of Low Bone Mineral Density and Its Associated Factors in Patients with Juvenile Systemic Lupus Erythematosus
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Frequency of Low Bone Mineral Density and Its Associated Factors in Patients with Juvenile Systemic Lupus Erythematosus

机译：幼年系统性红斑狼疮患者的低骨矿物质密度频率及其相关因素

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Objective: To evaluate the frequency of low bone mineral density (BMD) in Chinese patients with juvenile systemic lupus erythematosus (JSLE) and the associated protective and risk factors. Methods: We evaluated the BMD in 21 patients with JSLE with a mean age at diagnosis of 13.6±2.1 years. All patients had at least one BMD measurement by dual-energy X-ray absorptiometry at lumbar spine (L2-4) and femoral area at or beyond the age of 18. The correlations between BMD and cumulative dose of steroids, disease duration, disease activity, disease-related damage, clinical features, body mass index and age were investigated. Results: 'Low BMD for chronological age' (Z-score ≤-2.0) at one or more sites was seen in three patients (14.3%) and 'osteopenia' (Z-score -2.0) at any site was present in 12 patients (57.1%). Multiple linear regression analyses showed that body mass index was a positive predictor for BMD at all sites. Cumulative steroid dose, disease activity or lupus nephritis were not related to low BMD. Conclusions: Low bone mineral density is a common problem among Chinese patients with JSLE. Lower body mass index was shown to be a possible risk factor for low BMD.
机译：目的：评估中国青少年系统性红斑狼疮（JSLE）患者的低骨矿物质密度（BMD）频率及其相关的保护和危险因素。方法：我们评估了21例JSLE患者的BMD，平均年龄诊断为13.6±2.1岁。所有患者在18岁或超过18岁时通过腰椎（L2-4）和股骨区域的双能X线骨密度仪至少测量了一次BMD。BMD与类固醇累积剂量，疾病持续时间，疾病活动之间的相关性，疾病相关损害，临床特征，体重指数和年龄进行了调查。结果：三名患者（14.3％）出现一个或多个部位的“年龄年龄偏低的BMD”（Z分数≤-2.0），而12位患者中任一部位出现“骨质减少”（Z分数-2.0） （57.1％）。多元线性回归分析显示，体重指数是所有部位骨密度的阳性预测指标。累积类固醇剂量，疾病活动性或狼疮性肾炎与低骨密度无关。结论：骨矿物质密度低是中国JSLE患者常见的问题。较低的体重指数被证明是降低BMD的可能危险因素。

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