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首页> 外文期刊>Hong Kong Journal of Paediatrics >Presurgical Evaluation of Epileptogenic Focus in Temporal Lobe Epilepsy by 11C-Flumazenil PET and 123I-Iomazenil SPECT: A Case Report
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Presurgical Evaluation of Epileptogenic Focus in Temporal Lobe Epilepsy by 11C-Flumazenil PET and 123I-Iomazenil SPECT: A Case Report

机译： 11 C-氟马西尼PET和 123 I-伊马西尼SPECT术前评估癫痫灶在颞叶癫痫中的作用：一例报告

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摘要

Meticulous neuroradiological evaluations, including 123I-iomazenil (IMZ) single photon emission computed tomography (SPECT) and 11C-flumazenil (FMZ) positron emission tomography (PET), preoperatively disclosed epileptogenic foci in a 16-year-old boy with temporal lobe epilepsy. Interictal scalp electroencephalography showed spikes in the left temporal region. Left hippocampal sclerosis was seen on magnetic resonance imaging. Hypoperfusion in the entire left temporal lobe was seen on 99mTc ethyl-cysteinate dimer (ECD) SPECT. Hypometabolism over most of the left temporal lobe was apparent on 18F-fluorodeoxyglucose (FDG) PET. An area of hypoperfusion dominating the left temporal lobe was identified on 123I-IMZ SPECT. A low-uptake area in the left temporal lobe was seen on 11C-FMZ PET. Anteromedial temporal lobectomy and multiple subpial transection with intraoperative electrocorticography resulted in satisfactory seizure outcomes. Use of 123I-IMZ SPECT and 11C-FMZ PET appeared to demonstrate the epilepsy focus more localised than 99mTc ECD SPECT and 18F-FDG PET.
机译：术前进行了细致的神经放射学评估，包括 123 I-iomazenil（IMZ）单光子发射计算机断层扫描（SPECT）和 11 C-氟马西尼（FMZ）正电子发射断层扫描（PET）公开了在患有颞叶癫痫的16岁男孩中的致癫痫灶。头皮间脑电图显示左侧颞区有尖峰。磁共振成像发现左海马硬化。在 99m Tc半胱氨酸乙酯二聚体（ECD）SPECT上观察到整个左颞叶的灌注不足。在 18 F-氟脱氧葡萄糖（FDG）PET上，大多数左颞叶的代谢异常明显。在 123 I-IMZ SPECT上确定了占左颞叶低灌注的区域。在 11 C-FMZ PET上发现左颞叶低摄取区。颞内侧肺叶切除术和术中皮质皮质多处横突下横切术可以使癫痫发作令人满意。 123 I-IMZ SPECT和 11 C-FMZ PET的使用似乎表明癫痫病灶比 99m Tc ECD SPECT和 18 F-FDG PET。

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