• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hong Kong Journal of Paediatrics >Relationship Between HLA-DMA, DMB Allelesand Type 1 Diabetes in Chinese
【24h】

Relationship Between HLA-DMA, DMB Allelesand Type 1 Diabetes in Chinese

机译：中国人HLA-DMA，DMB等位基因与1型糖尿病的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Human Leucocyte Antigen (HLA)-DMA and DMB genes are located in the HLA-D region between DQ and DP. HLA-DM molecules play an important role in the process of peptide loading to HLA class II antigens, both in regulating the dissociation of class II-associated invariant chain peptides (CLIP) and the subsequent binding of exogenous peptides to HLA class II molecules. In order to investigate the immunogenetic heterogeneity within the HLA-D region, we designed this study to explore the relationship between HLA-DMA, DMB, and genetic susceptibility to type 1 diabetes in Chinese. Our results showed that HLA-DMA*0103 and HLA-DMB*0103 alleles contributed to the predisposition, while HLADMA*0102 and HLA-DMB*0101 alleles conferred protection to type 1 diabetes in Chinese. HLADMA*0101/0102 and DMB*0101/0101 genotypes were significantly increased in the controls, HLADMB*0103/0103 and DMA*0101/0103 genotypes were significantly increased in the patients. In Chinese, HLA-DMA*0102/DMB*0101 heterodimer confers protection to type 1 diabetes, while HLA-DMA*0103/ DMB*0102, DMA*0103/DMB*0103 and DMA*0103/DMB*0101 heterodimers confer susceptibility to type 1 diabetes. In general, our study suggests that HLA-DMA and DMB genes may be associated with the susceptibility to type 1 diabetes in Chinese.
机译：人类白细胞抗原（HLA）-DMA和DMB基因位于DQ和DP之间的HLA-D区域。 HLA-DM分子在调节加载到HLA II类抗原的肽的过程中起着重要作用，既调节II类相关的恒定链肽（CLIP）的解离，又是外源肽与HLA II类分子的随后结合。为了研究HLA-D区域内的免疫遗传异质性，我们设计了本研究，以探讨HLA-DMA，DMB与中国1型糖尿病的遗传易感性之间的关系。我们的结果表明，HLA-DMA * 0103和HLA-DMB * 0103等位基因是易感基因，而HLADMA * 0102和HLA-DMB * 0101等位基因为中国1型糖尿病提供了保护。对照中HLADMA * 0101/0102和DMB * 0101/0101基因型显着增加，患者中HLADMB * 0103/0103和DMA * 0101/0103基因型显着增加。在中文中，HLA-DMA * 0102 / DMB * 0101异二聚体可保护1型糖尿病，而HLA-DMA * 0103 / DMB * 0102，DMA * 0103 / DMB * 0103和DMA * 0103 / DMB * 0101异二聚体易感1型糖尿病。总的来说，我们的研究表明HLA-DMA和DMB基因可能与中国1型糖尿病的易感性有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号