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首页> 外文期刊>Hong Kong Journal of Paediatrics >Prevalence of Respiratory Function Abnormalities in Asymptomatic Chinese Patients with Juvenile Onset Systemic Lupus Erythematosus
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Prevalence of Respiratory Function Abnormalities in Asymptomatic Chinese Patients with Juvenile Onset Systemic Lupus Erythematosus

机译：中国无症状青少年系统性红斑狼疮患者呼吸功能异常的患病率

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Objectives: To determine the prevalence and features of respiratory function alterations in asymptomatic Chinese patients with juvenile onset systemic erythematosus (JSLE) and to assess its relationship with clinical and immunological parameters. Methods: Twenty-two Chinese patients with JSLE followed up at our Rheumatology Clinic were recruited. Each underwent pulmonary function test (PFT) and completed a respiratory questionnaire. Four were excluded because of past history of pulmonary disease. Abnormal respiratory function findings if present would be correlated with the disease duration, disease activity, organ involvement, clinical features and immunological findings using multiple regression analysis. Results: All 18 patients analysed were totally free of pulmonary symptoms and disease. Thirteen patients (72%) had abnormal PFT results. Ten patients (56%) had decreased diffusion capacity of the lung (DLCO). Among them, 2 had restrictive lung pattern and one had mixed pattern while 7 had isolated DLCO impairment. Disease duration and renal involvement were both found to be significantly associated with decreased DLCO (p=0.037 and p=0.035 respectively). However, both factors became insignificant after multiple regression analysis. Neurological lupus was significantly associated with decreased FEF 25-75% and FEF 75% (p value 0.03 and p<0.001 respectively). Conclusion: Asymptomatic Chinese patients with JSLE and no prior pulmonary involvement showed frequent PFT abnormalities with decreased DLCO being the most common impairment. Neurological involvement was the only factor found to be significantly associated with abnormal lung function parameters. We speculate that decreased DLCO could be related to high occurrence of SLE-associated pulmonary hypertension in Chinese. Further in-depth evaluation and long term follow up study is warranted.
机译：目的：确定无症状中国青少年系统性红斑（JSLE）患者的呼吸功能改变的患病率和特征，并评估其与临床和免疫学参数的关系。方法：招募了22名中国风湿病门诊的JSLE患者。每个人都进行了肺功能检查（PFT）并完成了呼吸问卷。由于过去的肺部疾病史，将四人排除在外。如果存在异常的呼吸功能发现，则使用多重回归分析将其与疾病持续时间，疾病活动，器官受累，临床特征和免疫学发现相关。结果：分析的所有18例患者完全没有肺部症状和疾病。 13名患者（72％）的PFT结果异常。十名患者（56％）的肺扩散能力（DLCO）降低。其中，2例为限制性肺型，1例为混合型，7例孤立的DLCO损伤。疾病持续时间和肾脏受累均与DLCO降低显着相关（分别为p = 0.037和p = 0.035）。但是，经过多元回归分析后，这两个因素都变得无关紧要。神经性狼疮与FEF降低25-75％和FEF 75％显着相关（p值分别为0.03和p <0.001）。结论：无症状的JSLE且无先前肺部受累的中国患者表现出频繁的PFT异常，最常见的损害是DLCO降低。发现神经系统受累是与异常肺功能参数显着相关的唯一因素。我们推测DLCO降低可能与中国SLE相关性肺动脉高压的高发生有关。有必要进行进一步的深入评估和长期随访研究。

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