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外文期刊>Hong Kong Journal of Paediatrics
>A Rare Complication of a Common Problem: Thrombocytopenia Subsequent to Iron Replacement Therapy in an Adolescent Girl with Severe Iron Deficiency Anaemia
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A Rare Complication of a Common Problem: Thrombocytopenia Subsequent to Iron Replacement Therapy in an Adolescent Girl with Severe Iron Deficiency Anaemia
Thrombocytosis may accompany iron deficiency anaemia (IDA). However, thrombocytopenia is a rare occurrence that might be associated with IDA. A 15-year-old girl presented with IDA related to menorrhagia. Erythrocyte transfusion was given, since the haemoglobin level at presentation was 4.7 g/dL and oral iron supplementation was initiated with ferrous glycine sulphate. On 12th day of iron treatment, platelet count was found to have decreased to a level of 48x109/L. Bone marrow aspiration was obtained in order to investigate the aetiology of thrombocytopenia and revealed erythroid hyperactivity, severe megaloblastic changes, binucleated normoblasts, and decreased number of megakaryocytes. Oral iron replacement therapy was continued and vitamin B12 was added to treatment in view of severe megaloblastic changes in the bone marrow examination. Platelet count normalised and haemoglobin level increased during the follow-up with the replacement of oral iron and vitamin B12.
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机译：血小板增多症可能伴有铁缺乏性贫血（IDA）。但是，血小板减少症是罕见的，可能与IDA相关。一名15岁女孩因IDA出现月经过多。由于出现的血红蛋白水平为4.7 g / dL，并且开始使用硫酸甘氨酸亚铁补充口服铁，因此进行了红细胞输血。铁治疗第12天，发现血小板计数降低至48x10 9 / L。为了研究血小板减少症的病因，进行了骨髓穿刺术，并发现了类红细胞亢进，严重的巨幼细胞改变，双核正常母细胞和巨核细胞数量减少。考虑到骨髓检查中严重的巨幼细胞改变，继续进行口服铁替代疗法并添加了维生素B12。在随访期间，随着口服铁和维生素B12的替换，血小板计数恢复正常，血红蛋白水平增加。
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