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首页> 外文期刊>Hong Kong Journal of Paediatrics >Is Hashimoto's Thyroiditis Associated with Chronic Immune Thrombocytopenic Purpura?
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Is Hashimoto's Thyroiditis Associated with Chronic Immune Thrombocytopenic Purpura?

机译：桥本甲状腺炎与慢性免疫性血小板减少性紫癜相关吗？

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Autoimmune disorders result from common process of disrupted self-tolerance. This describes why one autoimmune disease likely causes other autoimmune disorders.1 However, the literature about the occurrence of Hashimoto's thyroiditis (HT) in previously diagnosed immune thrombocytopenic purpura patients is rarely reported. As there is few data about this theme in children, we described 4-year-old boy who developed autoimmune thyroid disease in a year after the diagnosis of ITP. Three years old patient with an unremarkable medical and family history was admitted to our hospital with acute onset of bruising and petechiae on his cheeks, legs, arms and back. Physical examination revealed no other abnormalities. Laboratory studies showed an isolated thyrombocytopenia of 13000/L. After performing multiple diagnostic studies to exclude other hematologic and infectious disorders, the patient was diagnosed with immune thrombocytopenic purpura (ITP). Serum tests were negative for anti-EBV and anti-CMV IgM antibodies. Methylprednisone (30 mg/kg/day), intravenous immunoglobulin (2 gr/kg/dosage IVIG) and WinRho (60 mcg/kg/day Anti-D) were administered. After these treatments, his platelet count increased. The patient received methylprednisone (30 mg/kg/day), IVIG (1 gr/kg/dosage) or WinRho (60 mcg/kg/day) for persisting thyrombocytopenia (8000-20000/L) with an interval of one month in first six months. Serologies for HIV and HTLV, ANA and anti dsDNA autoantibodies were negative. Subsequently IVIG (1 gr/kg/dosage), dexamethasone (28 mg/m2/day) and vincristine (1.5 mg/m2/dosage) were administered for persisting thyrombocytopenia (8000-20000/L) in following four months. After ten months, cyclosporine was started, but thyrombocytopenia persisted (8000-20000/L). The patient was diagnosed with chronic immune thrombocytopenic purpura (ITP). While we were performing multiple diagnostic studies, the patient showed elevated levels of antithyroid antibodies [antiperoxidase antibody (TPO): 361.67 IU/mL (
机译：自身免疫性疾病是由于自我耐受能力下降的常见过程导致的。这说明了为什么一种自身免疫性疾病可能引起其他自身免疫性疾病的原因。 1 但是，鲜有关于先前诊断为免疫性血小板减少性紫癜患者的桥本甲状腺炎（HT）发生的文献。由于关于儿童的这一主题的数据很少，我们描述了在ITP诊断后一年内发展为自身免疫性甲状腺疾病的4岁男孩。三岁患者，病史和家族史不明显，因双颊，四肢，手臂和背部严重瘀伤和瘀斑而入院。体格检查未发现其他异常。实验室研究显示，孤立的血小板减少症为13000 / L。在进行了多项诊断研究以排除其他血液学和感染性疾病后，该患者被诊断患有免疫性血小板减少性紫癜（ITP）。血清测试显示抗EBV和抗CMV IgM抗体阴性。给予甲基泼尼松（30 mg / kg /天），静脉内免疫球蛋白（2 gr / kg /剂量IVIG）和WinRho（60 mcg / kg /天Anti-D）。经过这些治疗后，他的血小板计数增加了。该患者因持续性血小板减少症（8000-20000 / L）而接受甲泼尼龙（30 mg / kg /天），IVIG（1 gr / kg /天）或WinRho（60 mcg / kg /天），间隔为一个月六个月。 HIV和HTLV，ANA和抗dsDNA自身抗体血清学均为阴性。随后给予IVIG（1 gr / kg /剂量），地塞米松（28 mg / m 2 /天）和长春新碱（1.5 mg / m 2 /剂量）持续服用随后四个月出现血小板减少症（8000-20000 / L）。十个月后，开始使用环孢菌素，但血小板减少症持续存在（8000-20000 / L）。该患者被诊断出患有慢性免疫性血小板减少性紫癜（ITP）。当我们进行多项诊断研究时，患者显示抗甲状腺抗体[抗过氧化物酶抗体（TPO）：361.67 IU / mL（

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