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首页> 外文期刊>Hong Kong Journal of Paediatrics >Evolution of Diseases or Disease Manifestations
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Evolution of Diseases or Disease Manifestations

机译：疾病或疾病表现的演变

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With the advances in medical technology, we are experiencing changes in disease spectrum or disease manifestations. Based on the "hygiene theory", allergy is likely in part related to urbanisation. Children in Amazon forest, rural area of Beijing, and the farmland of Netherlands seldom have asthma, eczema or allergic rhinitis as compare to their counterparts living in the city ( Prof. Le Sou?lf PL, Elaine Field Lecture 2007 ). The essence of this theory is that early exposure to common pathogens will switch on the "T-helper 1 lymphocytes" response which targets at foreign invaders. While delay exposure to these pathogens will switch on the "T-helper 2 lymphocytes" response which is usually associated with allergic reaction. Now we know that such T-helper cells polarisation is consists of 5 different types and each of them have distinct function, including either immuno-stimulatory (i.e. Th-1, Th-2 or Th17) or immuno-tolerant (i.e. T-reg) in nature. In this issue, the article by Kim HH, et al. is supporting this theory. House dust mite is virtually present in all modern household and in some countries, the rise in the house dust mites in winter season is caused by the use of warmer and decrease in air ventilation within the room due to the cold weather. The association of elevated house dust mite specific IgE levels in those presenting with asthma suggests house dust mite sensitisation as a risk factor for their exacerbation in winter. We all noticed that the prevalence of allergic illnesses has been on a rising trends and how can we prevent it from occurring will be our next challenge.
机译：随着医疗技术的进步，我们正在经历疾病谱或疾病表现的变化。基于“卫生理论”，过敏可能部分与城市化有关。与住在城市的同龄人相比，亚马逊森林，北京农村地区和荷兰农田中的儿童很少患有哮喘，湿疹或过敏性鼻炎（Le Sou？lf PL教授，Elaine Field Lecture 2007）。该理论的实质是，早期暴露于常见病原体将打开针对外来入侵者的“ T-helper 1淋巴细胞”反应。虽然延迟暴露于这些病原体会打开“ T-helper 2淋巴细胞”反应，这通常与过敏反应有关。现在我们知道，这种T辅助细胞的极化由5种不同的类型组成，它们各自具有独特的功能，包括免疫刺激（即Th-1，Th-2或Th17）或免疫耐受（即T-reg ） 在自然界。在本期中，Kim HH等人的文章。支持这一理论。室内尘螨实际上存在于所有现代家庭中，并且在某些国家/地区，冬季使用室内尘螨的原因是由于使用更暖的温度以及由于寒冷天气导致室内空气流通减少所致。哮喘患者中屋尘螨特定IgE水平升高的相关性表明，屋尘螨致敏性是其冬季加剧病情的危险因素。我们所有人都注意到，过敏性疾病的流行趋势一直在上升，而如何防止其发生将是我们的下一个挑战。

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