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Ototoxicity in Chinese Osteosarcoma Children Treated with Cisplatin

机译：顺铂治疗中国骨肉瘤儿童的耳毒性

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Objective: To evaluate the ototoxicity of cisplatin in Chinese children who were suffered from osteosarcoma. Patients & Methods: Restrospective case series of Chinese children who were treated in a tertiary referral centre of Hong Kong. Data was based on hospital records of children who were suffering from osteosarcoma between 1994 and 2001. They all have cisplatin treatment with pre- and post-chempotherapy pure tone audiometry results. Results: Sixteen patients fulfied the inclusion criterias were studied. Nineteen percent had grade I hearing impairment even at baseline evaluation. Sixty-nine percent showed worsening of the hearing after cisplatin treatment. The hearing threshold was increased at 2000Hz after cisplatin, which was more clearly shown at 4000Hz and 8000Hz. The results were statistically significant with the p-value 0.011, 0.003 and 0.002 respectively. Conclusion: Cisplatin would damage the hearing particularly at high frequency range (2000Hz, 4000Hz and 8000Hz). The hearing at low frequency range was relatively spare.
机译：目的：评价顺铂对中国儿童骨肉瘤的耳毒性。患者与方法：回顾性病例系列病例在香港三级转诊中心接受治疗。数据基于1994年至2001年患骨肉瘤的儿童的医院记录。他们均接受顺铂治疗以及化疗前后的纯音测听结果。结果：对符合入选标准的16例患者进行了研究。即使在进行基线评估时，仍有19％的人患有I级听力障碍。顺铂治疗后有69％的患者表现出听力恶化。顺铂治疗后，听力阈值在2000Hz时增加，这在4000Hz和8000Hz时更明显。结果具有统计学意义，p值分别为0.011、0.003和0.002。结论：顺铂会损害听力，尤其是在高频范围（2000Hz，4000Hz和8000Hz）下。低频范围的听觉相对较闲。

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