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首页> 外文期刊>Human Veterinary Medicine-International Journal of the Bioflux Society >Are non-invasive scores reliable for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis diagnostic?.
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Are non-invasive scores reliable for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis diagnostic?.

机译：非侵入性评分对非酒精性脂肪肝疾病和非酒精性脂肪性肝炎的诊断是否可靠？

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Objective: the aim of this study was to evaluate the value of four biological markers (fatty liver index - FLI, Steatotest - ST, ASTto platelet ratio - APRI, hepatic steatosis index - HSI) for the diagnosis and staging of NAFLD and for the diagnosis of NASH. Material andMethods: We prospectively included 112 patients with biopsy-proven NAFLD in our study. The histological features were evaluated using theKleiner score. Four biological markers (FLI, ST, APRI and HIS) were used for the non-invasive assessment of steatosis and steatohepatitis.Results: Three biological scores proved to have a good discriminative ability in differentiating between various stages of steatosis (p=0.05 forFLI, 0.04 for ST and 0.005 for HIS). All these scores proved reliable in the diagnosis of moderate steatosis (p=0.01 for FLI and ST and 0.001for HSI). We did not find a significant statistical difference between most scores when used for the diagnosis of NASH, except for the APRIscore (p=0.04). Conclusion: ST, FLI and HIS are reliable tests for the diagnosis and staging of NAFLD, besides being precise, non-expensiveand easy to use. APRI, a score for fibrosis, was correlated with NASH and should draw attention to the presence of NASH in patients with hepaticsteatosis.
机译：目的：本研究的目的是评估四种生物学指标（脂肪肝指数-FLI，Steatotest-ST，ASTto血小板比率-APRI，肝脂肪变性指数-HSI）对NAFLD的诊断和分期以及诊断的价值NASH。材料和方法：我们前瞻性地纳入了112例经活检证实的NAFLD患者。使用Kleiner评分评估组织学特征。 FLI，ST，APRI和HIS四个生物学标记用于脂肪变性和脂肪性肝炎的非侵入性评估。结果：三个生物学评分被证明具有区分脂肪变性不同阶段的良好区分能力（对于FLI，p = 0.05， ST为0.04，HIS为0.005）。所有这些得分均被证明可用于中度脂肪变性的诊断（FLI和ST为p = 0.01，HSI为<0.001）。除APRIscore（p = 0.04）外，我们在用于NASH诊断的大多数评分之间均未发现显着的统计学差异。结论：ST，FLI和HIS是精确，非昂贵且易于使用的可靠方法，可用于诊断和诊断NAFLD。 APRI（纤维化评分）与NASH相关，应引起肝硬化患者NASH的存在。

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