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首页> 外文期刊>Danishgah-i Ulum-i Pizishki va Khadamat-i Bihdashti-Darmani Shahid Sadugi Yazd. Majallah >Comparison of Serum TNF-Α, Interleukin-10, Interferon Gamma and Interleukin-12 Levels in Mycobacterium Tuberculosis and Non-Tuberculosis Patients
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Comparison of Serum TNF-Α, Interleukin-10, Interferon Gamma and Interleukin-12 Levels in Mycobacterium Tuberculosis and Non-Tuberculosis Patients

机译：结核分枝杆菌和非结核分枝杆菌患者血清TNF-α，白细胞介素10，干扰素γ和白细胞介素12水平的比较

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Introduction: Determination of produced cytokines, especially interleukin 10, interleukin 12, interferon gamma and TNF-α is an important tool in the review of safety responses against inducers such as illnesses. The purpose of this study was to investigate the immune system status in patients with mycobacterium infections such as tuberculosis and non-tuberculosis as compared to healthy controls and find the relationship of these values with the diseases and their distribution.Methods: Blood sampling was performed on 87 infected patients with mycobacterium infection referring to the Mycobacteriology Research Center. Patients were divided into two groups of nontuberculosis mycobacterium (MOTT) (27 patients) and tuberculosis mycobacterium (60 patients). Also, 86 healthy controls were selected. Cytokines serum values were determined by ELISA test. Results: In this study, the control group included 86 people, the tuberculosis mycobacterium group included 60 people and the MOTT group included 27 people. IL-10and IFN-γ levels were significantly more in infected people with mycobacterium tuberculosis and mycobacterium nontuberculosis infection as compared to the healthy controls , whereas the difference in serum TNF-α and IL-12 levels was not statistically significant.Conclusion: According to the results obtained in this study, increased serum values of IL-10 and interferon gamma are related with disease progression, while IL-12 and α-TNF serum values are not affected significantly in disease.
机译：简介：确定产生的细胞因子，尤其是白介素10，白介素12，干扰素γ和TNF-α是审查针对疾病等诱导物的安全性反应的重要工具。这项研究的目的是调查与健康对照相比结核分枝杆菌感染和非结核分枝杆菌感染患者的免疫系统状况，并找出这些值与疾病及其分布之间的关系。参考分枝杆菌研究中心的87名分枝杆菌感染患者。将患者分为非结核分枝杆菌（MOTT）和结核分枝杆菌（60例）两组。另外，选择了86个健康对照。通过ELISA测试确定细胞因子血清值。结果：本研究中，对照组为86人，结核分枝杆菌组为60人，MOTT组为27人。与健康对照组相比，结核分枝杆菌和非结核分枝杆菌感染者的IL-10和IFN-γ水平明显更高，而血清TNF-α和IL-12水平的差异无统计学意义。在这项研究中获得的结果表明，IL-10和干扰素γ的血清值升高与疾病进展有关，而IL-12和α-TNF的血清值在疾病中并未受到显着影响。

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