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New mutant phenotype data curation system in the Saccharomyces Genome Database

机译：酿酒酵母基因组数据库中的新的突变表型数据管理系统

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The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) organizes and displays molecular and genetic information about the genes and proteins of baker's yeast, Saccharomyces cerevisiae. Mutant phenotype screens have been the starting point for a large proportion of yeast molecular biological studies, and are still used today to elucidate the functions of uncharacterized genes and discover new roles for previously studied genes. To greatly facilitate searching and comparison of mutant phenotypes across genes, we have devised a new controlled-vocabulary system for capturing phenotype information. Each phenotype annotation is represented as an ‘observable', which is the entity, or process that is observed, and a ‘qualifier' that describes the change in that entity or process in the mutant (e.g. decreased, increased, or abnormal). Additional information about the mutant, such as strain background, allele name, conditions under which the phenotype is observed, or the identity of relevant chemicals, is captured in separate fields. For each gene, a summary of the mutant phenotype information is displayed on the Locus Summary page, and the complete information is displayed in tabular format on the Phenotype Details Page. All of the information is searchable and may also be downloaded in bulk using SGD's Batch Download Tool or Download Data Files Page. In the future, phenotypes will be integrated with other curated data to allow searching across different types of functional information, such as genetic and physical interaction data and Gene Ontology annotations. Database URL: http://www.yeastgenome.org/
机译：酿酒酵母基因组数据库（SGD; http://www.yeastgenome.org/）组织并显示有关面包酵母啤酒酵母的基因和蛋白质的分子和遗传信息。突变表型筛选已成为大部分酵母分子生物学研究的起点，并且今天仍用于阐明未表征基因的功能并发现先前研究的基因的新作用。为了极大地促进跨基因的突变表型的搜索和比较，我们设计了一种新的受控词汇系统来捕获表型信息。每个表型注释均表示为“可观察”，即观察到的实体或过程，以及“限定词”，描述了突变体中该实体或过程的变化（例如，减少，增加或异常）。有关突变体的其他信息，例如菌株背景，等位基因名称，观察表型的条件或相关化学物质的身份，均在单独的字段中捕获。对于每个基因，突变体表型信息的摘要显示在“基因座摘要”页面上，完整信息以表格格式显示在“表型详细信息”页面上。所有信息都是可搜索的，也可以使用SGD的“批量下载工具”或“下载数据文件”页面进行批量下载。将来，表型将与其他精选数据整合在一起，以允许在不同类型的功能信息中进行搜索，例如遗传和物理相互作用数据以及基因本体注释。数据库网址：http://www.yeastgenome.org/

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