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The systematic annotation of the three main GPCR families in Reactome

机译：Reactome中三个主要GPCR家族的系统注释

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摘要

Reactome is an open-source, freely available database of human biological pathways and processes. A major goal of our work is to provide an integrated view of cellular signalling processes that spans from ligand–receptor interactions to molecular readouts at the level of metabolic and transcriptional events. To this end, we have built the first catalogue of all human G protein-coupled receptors (GPCRs) known to bind endogenous or natural ligands. The UniProt database has records for 797 proteins classified as GPCRs and sorted into families A/1, B/2 and C/3 on the basis of amino accid sequence. To these records we have added details from the IUPHAR database and our own manual curation of relevant literature to create reactions in which 563 GPCRs bind ligands and also interact with specific G-proteins to initiate signalling cascades. We believe the remaining 234 GPCRs are true orphans. The Reactome GPCR pathway can be viewed as a detailed interactive diagram and can be exported in many forms. It provides a template for the orthology-based inference of GPCR reactions for diverse model organism species, and can be overlaid with protein–protein interaction and gene expression datasets to facilitate overrepresentation studies and other forms of pathway analysis. Database URL: http://www.reactome.org
机译：Reactome是一个开放源代码，可免费获取的人类生物学途径和过程数据库。我们工作的主要目标是提供细胞信号传导过程的完整视图，该过程涵盖从配体-受体相互作用到代谢和转录事件水平的分子读数。为此，我们已经建立了已知能与内源或天然配体结合的所有人类G蛋白偶联受体（GPCR）的第一本目录。 UniProt数据库记录了797种蛋白质的记录，这些蛋白质被分类为GPCR，并根据氨基酸序列分为A / 1，B / 2和C / 3家族。在这些记录中，我们从IUPHAR数据库和我们自己的相关文献手册中添加了详细信息，以创建其中563个GPCR结合配体并且还与特定G蛋白相互作用以引发信号级联的反应。我们认为其余234个GPCR是真正的孤儿。 Reactome GPCR途径可以看作是详细的交互图，并且可以多种形式导出。它为各种模型生物物种的基于正交学的GPCR反应推论提供了模板，并且可以覆盖蛋白质-蛋白质相互作用和基因表达数据集，以促进过度表达研究和其他形式的途径分析。数据库URL：http://www.reactome.org

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