• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Database >EuroDia: a beta-cell gene expression resource
【24h】

EuroDia: a beta-cell gene expression resource

机译：EuroDia：β细胞基因表达资源

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Type 2 diabetes mellitus (T2DM) is a major disease affecting nearly 280 million people worldwide. Whilst the pathophysiological mechanisms leading to disease are poorly understood, dysfunction of the insulin-producing pancreatic beta-cells is key event for disease development. Monitoring the gene expression profiles of pancreatic beta-cells under several genetic or chemical perturbations has shed light on genes and pathways involved in T2DM. The EuroDia database has been established to build a unique collection of gene expression measurements performed on beta-cells of three organisms, namely human, mouse and rat. The Gene Expression Data Analysis Interface (GEDAI) has been developed to support this database. The quality of each dataset is assessed by a series of quality control procedures to detect putative hybridization outliers. The system integrates a web interface to several standard analysis functions from R/Bioconductor to identify differentially expressed genes and pathways. It also allows the combination of multiple experiments performed on different array platforms of the same technology. The design of this system enables each user to rapidly design a custom analysis pipeline and thus produce their own list of genes and pathways. Raw and normalized data can be downloaded for each experiment. The flexible engine of this database (GEDAI) is currently used to handle gene expression data from several laboratory-run projects dealing with different organisms and platforms. Database URL: http://eurodia.vital-it.ch
机译：2型糖尿病（T2DM）是一种主要疾病，在全球范围内影响着近2.8亿人。尽管对导致疾病的病理生理机制了解甚少，但产生胰岛素的胰岛β细胞功能异常是疾病发展的关键事件。在几种遗传或化学扰动下监测胰腺β细胞的基因表达谱，为T2DM所涉及的基因和途径提供了启示。已经建立了EuroDia数据库，以建立对三种生物（即人，小鼠和大鼠）的β细胞进行基因表达测量的独特集合。已经开发了基因表达数据分析接口（GEDAI）以支持该数据库。通过一系列质量控制程序评估每个数据集的质量，以检测推定的杂交离群值。该系统将Web界面与R / Bioconductor的几种标准分析功能集成在一起，以识别差异表达的基因和途径。它还允许组合在相同技术的不同阵列平台上执行的多个实验。该系统的设计使每个用户都能快速设计定制的分析管道，从而产生自己的基因和途径清单。可以为每个实验下载原始数据和标准化数据。该数据库的灵活引擎（GEDAI）当前用于处理来自几个实验室运行项目的基因表达数据，这些项目涉及不同的生物和平台。数据库网址：http://eurodia.vital-it.ch

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号