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OpenFluDB, a database for human and animal influenza virus

机译：OpenFluDB，人类和动物流感病毒的数据库

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Although research on influenza lasted for more than 100 years, it is still one of the most prominent diseases causing half a million human deaths every year. With the recent observation of new highly pathogenic H5N1 and H7N7 strains, and the appearance of the influenza pandemic caused by the H1N1 swine-like lineage, a collaborative effort to share observations on the evolution of this virus in both animals and humans has been established. The OpenFlu database (OpenFluDB) is a part of this collaborative effort. It contains genomic and protein sequences, as well as epidemiological data from more than 27 000 isolates. The isolate annotations include virus type, host, geographical location and experimentally tested antiviral resistance. Putative enhanced pathogenicity as well as human adaptation propensity are computed from protein sequences. Each virus isolate can be associated with the laboratories that collected, sequenced and submitted it. Several analysis tools including multiple sequence alignment, phylogenetic analysis and sequence similarity maps enable rapid and efficient mining. The contents of OpenFluDB are supplied by direct user submission, as well as by a daily automatic procedure importing data from public repositories. Additionally, a simple mechanism facilitates the export of OpenFluDB records to GenBank. This resource has been successfully used to rapidly and widely distribute the sequences collected during the recent human swine flu outbreak and also as an exchange platform during the vaccine selection procedure. Database URL: http://openflu.vital-it.ch.
机译：尽管对流感的研究持续了100多年，但它仍然是每年导致半百万人死亡的最突出的疾病之一。随着最近对新的高致病性H5N1和H7N7菌株的观察，以及由H1N1猪样谱系引起的流感大流行的出现，人们建立了共同的努力，以分享对这种病毒在动物和人类中的进化的观察。 OpenFlu数据库（OpenFluDB）是此协作工作的一部分。它包含基因组和蛋白质序列，以及来自27,000多个分离株的流行病学数据。分离株注释包括病毒类型，宿主，地理位置和经过实验测试的抗病毒抗性。从蛋白质序列计算推定的致病性和人类适应倾向。每个病毒分离株都可以与收集，测序和提交它的实验室相关联。包括多重序列比对，系统发育分析和序列相似性图在内的多种分析工具可实现快速有效的挖掘。 OpenFluDB的内容由直接用户提交以及通过每天自动过程从公共存储库导入数据来提供。此外，一种简单的机制有助于将OpenFluDB记录导出到GenBank。此资源已成功用于迅速和广泛地分配在最近的人类猪流感暴发期间收集的序列，并已在疫苗选择过程中用作交换平台。数据库URL：http：//openflu.vital-it.ch。

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