iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

Andrei L. Turinsky; Brian Turner; Edgard K. Crowdy; Emerson Cho; Ian M. Donaldson; James Vlasblom; Kyle Morrison; Sabry Razick; Shoshana J. Wodak

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iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

机译：iRefWeb：整合蛋白相互作用数据及其支持证据的交互式分析

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We present iRefWeb, a web interface to protein interaction data consolidated from 10 public databases: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI and OPHID. iRefWeb enables users to examine aggregated interactions for a protein of interest, and presents various statistical summaries of the data across databases, such as the number of organism-specific interactions, proteins and cited publications. Through links to source databases and supporting evidence, researchers may gauge the reliability of an interaction using simple criteria, such as the detection methods, the scale of the study (high- or low-throughput) or the number of cited publications. Furthermore, iRefWeb compares the information extracted from the same publication by different databases, and offers means to follow-up possible inconsistencies. We provide an overview of the consolidated protein–protein interaction landscape and show how it can be automatically cropped to aid the generation of meaningful organism-specific interactomes. iRefWeb can be accessed at: http://wodaklab.org/iRefWeb. Database URL: http://wodaklab.org/iRefWeb/

机译：我们介绍iRefWeb，这是一个从10个公共数据库整合的蛋白质相互作用数据的Web界面：BIND，BioGRID，CORUM，DIP，IntAct，HPRD，MINT，MPact，MPPI和OPHID。 iRefWeb使用户能够检查目标蛋白质的聚合相互作用，并在整个数据库中显示各种数据的统计摘要，例如生物体特异性相互作用，蛋白质和引用出版物的数量。通过链接到源数据库和支持证据，研究人员可以使用简单的标准（例如检测方法，研究规模（高通量或低通量）或引用的出版物数量）来评估相互作用的可靠性。此外，iRefWeb会比较不同数据库从同一出版物中提取的信息，并提供跟踪可能出现的不一致的方法。我们提供了整合的蛋白质-蛋白质相互作用图景的概述，并展示了如何将其自动裁剪以帮助生成有意义的生物特异性相互作用组。可以从以下网站访问iRefWeb：http：//wodaklab.org/iRefWeb。数据库URL：http://wodaklab.org/iRefWeb/

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《Database》 |2010年第1期|共页
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Andrei L. Turinsky; Brian Turner; Edgard K. Crowdy; Emerson Cho; Ian M. Donaldson; James Vlasblom; Kyle Morrison; Sabry Razick; Shoshana J. Wodak;
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iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

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