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A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools

机译：网络驱动的数据探索工具增强了基于Web的皮肤黑素瘤遗传关联研究数据库

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The publicly available online database MelGene provides a comprehensive, regularly updated, collection of data from genetic association studies in cutaneous melanoma (CM), including random-effects meta-analysis results of all eligible polymorphisms. The updated database version includes data from 192 publications with information on 1114 significantly associated polymorphisms across 280 genes, along with new front-end and back-end capabilities. Various types of relationships between data are calculated and visualized as networks. We constructed 13 different networks containing the polymorphisms and the genes included in MelGene. We explored the derived network representations under the following questions: (i) are there nodes that deserve consideration regarding their network connectivity characteristics? (ii) What is the relation of either the genome-wide or nominally significant CM polymorphisms/genes with the ones highlighted by the network representation? We show that our network approach using the MelGene data reveals connections between statistically significant genes/?polymorphisms and other genes/polymorphisms acting as ‘hubs' in the reconstructed networks. To the best of our knowledge, this is the first database containing data from a comprehensive field synopsis and systematic meta-analyses of genetic polymorphisms in CM that provides user-friendly tools for in-depth molecular network visualization and exploration. The proposed network connections highlight potentially new loci requiring further investigation of their relation to melanoma risk. Database URL: http://www.melgene.org.
机译：公开可用的在线数据库MelGene提供了来自皮肤黑素瘤（CM）遗传关联研究的全面，定期更新的数据收集，包括所有符合条件的多态性的随机效应荟萃分析结果。更新后的数据库版本包括来自192个出版物的数据，其中包含有关280个基因的1114个显着相关的多态性的信息，以及新的前端和后端功能。数据之间的各种类型的关系被计算并可视化为网络。我们构建了13个包含多态性和MelGene中包含的基因的不同网络。我们在以下问题下探索了派生的网络表示形式：（i）是否存在值得考虑的网络连接特性节点？ （ii）全基因组或名义上重要的CM多态性/基因与网络表示法所强调的基因多态性/基因有什么关系？我们表明，使用MelGene数据的网络方法揭示了统计上重要的基因/多态性与其他基因/多态性之间的联系，这些基因/多态性在重构网络中充当“集线器”。据我们所知，这是第一个包含来自CM中遗传多态性的全面现场简介和系统性荟萃分析的数据的数据库，该数据库为深入的分子网络可视化和探索提供了用户友好的工具。拟议的网络连接突出了潜在的新基因座，需要进一步研究其与黑素瘤风险的关系。数据库URL：http：//www.melgene.org。

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