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StaphyloBase: a specialized genomic resource for the staphylococcal research community

机译：StaphyloBase：葡萄球菌研究社区的专业基因组资源

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With the advent of high-throughput sequencing technologies, many staphylococcal genomes have been sequenced. Comparative analysis of these strains will provide better understanding of their biology, phylogeny, virulence and taxonomy, which may contribute to better management of diseases caused by staphylococcal pathogens. We developed StaphyloBase with the goal of having a one-stop genomic resource platform for the scientific community to access, retrieve, download, browse, search, visualize and analyse the staphylococcal genomic data and annotations. We anticipate this resource platform will facilitate the analysis of staphylococcal genomic data, particularly in comparative analyses. StaphyloBase currently has a collection of 754 032 protein-coding sequences (CDSs), 19 258 rRNAs and 15 965 tRNAs from 292 genomes of different staphylococcal species. Information about these features is also included, such as putative functions, subcellular localizations and gene/protein sequences. Our web implementation supports diverse query types and the exploration of CDS- and RNA-type information in detail using an AJAX-based real-time search system. JBrowse has also been incorporated to allow rapid and seamless browsing of staphylococcal genomes. The Pairwise Genome Comparison tool is designed for comparative genomic analysis, for example, to reveal the relationships between two user-defined staphylococcal genomes. A newly designed Pathogenomics Profiling Tool (PathoProT) is also included in this platform to facilitate comparative pathogenomics analysis of staphylococcal strains. In conclusion, StaphyloBase offers access to a range of staphylococcal genomic resources as well as analysis tools for comparative analyses. Database URL: http://staphylococcus.um.edu.my/
机译：随着高通量测序技术的出现，许多葡萄球菌基因组已被测序。对这些菌株进行比较分析，可以更好地了解其生物学，系统发育，毒力和分类学，从而有助于更好地管理由葡萄球菌病原体引起的疾病。我们开发StaphyloBase的目的是为科学界提供一站式基因组资源平台，以访问，检索，下载，浏览，搜索，可视化和分析葡萄球菌基因组数据和注释。我们预计该资源平台将有助于葡萄球菌基因组数据的分析，尤其是在比较分析中。 StaphyloBase目前具有来自不同葡萄球菌物种的292个基因组的754 032个蛋白质编码序列（CDS），19 258个rRNA和15 965 tRNA的集合。还包括有关这些功能的信息，例如推定功能，亚细胞定位和基因/蛋白质序列。我们的Web实施使用基于AJAX的实时搜索系统支持各种查询类型以及对CDS和RNA类型信息的详细探索。 JBrowse还被并入以允许快速无缝地浏览葡萄球菌基因组。成对基因组比较工具旨在进行比较基因组分析，例如，揭示两个用户定义的葡萄球菌基因组之间的关系。该平台还包括新设计的病原学分析工具（PathoProT），以促进葡萄球菌菌株的比较病原学分析。总之，StaphyloBase提供了一系列葡萄球菌基因组资源以及用于比较分析的分析工具。数据库URL：http://staphylococcus.um.edu.my/

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