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首页> 外文期刊>Zoologia (Curitiba) >Isolation and sequencing of the HMG domain of ten Sox genes from Odorrana schmackeri (Amphibia: Anura)
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Isolation and sequencing of the HMG domain of ten Sox genes from Odorrana schmackeri (Amphibia: Anura)

机译：Odorrana schmackeri（Amphibia：Anura）的10个Sox基因的HMG结构域的分离和测序

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摘要

Sox (SRY-related HMG-box) genes encode a family of transcriptional regulators, which are characterized by a conserved 79-amino acid domain known as HMG-box. They play essential roles in a diverse range of processes including sex determination and the development of the central nervous system (CNS), neural crest and endoderm. In this paper, the HMG domain of ten distinct Sox gene family members (os-Sox2, os-Sox3a, os-Sox3b, os-Sox4, os-Sox11a, os-Sox11b, os-Sox14a, os-Sox14b, os-Sox21a, os-Sox21b) were isolated from both male and female Odorrana schmackeri (Boettger, 1892) using PCR, and no sexual differences were found. Molecular phylogenetic analysis of the HMG domain suggested that these ten Sox genes are members of the SoxB and SoxC groups. In addition, sequence analysis suggested that four Sox genes (os-Sox3, os-Sox11, os-Sox14, os-Sox21) were duplicated. The duplication-degeneration-complementation model should be implied to explain the evolution and diversity of the Sox gene family in O. schmackeri.
机译：Sox（与SRY相关的HMG-box）基因编码一系列转录调节因子，其特征是一个保守的79个氨基酸的结构域，称为HMG-box。它们在包括性别确定和中枢神经系统（CNS），神经c和内胚层发育在内的各种过程中起着至关重要的作用。本文介绍了十个不同的Sox基因家族成员（os-Sox2，os-Sox3a，os-Sox3b，os-Sox4，os-Sox11a，os-Sox11b，os-Sox14a，os-Sox14b，os-Sox21a）的HMG域使用PCR方法从雄性和雌性Odorrana schmackeri（Boettger，1892）分离出os-Sox21b），未发现性别差异。 HMG域的分子系统发育分析表明，这十个Sox基因是SoxB和SoxC组的成员。另外，序列分析表明四个Sox基因（os-Sox3，os-Sox11，os-Sox14，os-Sox21）被复制。应该暗示复制-变性-互补模型来解释O. schmackeri中Sox基因家族的进化和多样性。

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