Cell adhesion molecules in Alzheimer's disease

Malin Wennstr?m; Henrietta M Nielsen

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Cell adhesion molecules in Alzheimer's disease

机译：阿尔茨海默氏病中的细胞粘附分子

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Abstract: Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also mediate mechanisms involved in several neurological diseases. This article reviews the current knowledge on the role of CAMs in amyloid-? (A?) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer's disease (AD). This paper also outlines the possible roles of CAMs in current and novel AD treatment strategies.

机译：摘要：细胞粘附分子（CAM）介导细胞与周围环境之间的相互作用，这对于控制细胞存活，活化，迁移和可塑性的过程至关重要。但是，越来越多的证据表明，CAM也介导了几种神经系统疾病的机制。本文回顾了有关CAMs在淀粉样蛋白中作用的最新知识。（A）代谢，细胞可塑性，神经炎症和血管变化，所有这些都被认为是阿尔茨海默氏病（AD）发病机理和进展的关键。本文还概述了CAM在当前和新型AD治疗策略中的可能作用。

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《Degenerative Neurological and Neuromuscular Disease》 |2012年第2003期|共13页
作者
Malin Wennstr?m; Henrietta M Nielsen;
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Cell adhesion molecules in Alzheimer's disease

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