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首页> 外文期刊>Degenerative Neurological and Neuromuscular Disease >The relationship between the apolipoprotein E e4 allele and hippocampal magnetic resonance imaging volume in community-dwelling individuals with mild Alzheimer's disease
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The relationship between the apolipoprotein E e4 allele and hippocampal magnetic resonance imaging volume in community-dwelling individuals with mild Alzheimer's disease

机译：轻度阿尔茨海默氏病社区居民载脂蛋白E e4等位基因与海马磁共振成像量的关系

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Background: The degree of hippocampal magnetic resonance imaging (MRI) volume loss in Alzheimer's disease (AD) is commonly accepted as a marker of disease severity, yet remains expensive, unavailable, or not tolerated by many patients. Aim: To examine whether the presence of one or more apolipoprotein E (ApoE) e4 alleles is associated with smaller hippocampal MRI volumes in a population of early AD patients. Methods: A total of 88 consecutive patients attending a community-based memory disorders clinic who had both mild dementia on the Clinical Dementia Rating scale and Diagnostic and Statistical Manual of Mental Disorders criteria for probable AD were recruited. We examined the relationship between ApoE e4 allele load and hippocampal atrophy on MRI volumes. Results: There was no association between the ApoE e4 load and hippocampal volume in this cohort. Conclusion: This study suggests that the presence of one or more ApoE e4 alleles cannot be used to estimate pathological disease load in early AD.
机译：背景：阿尔茨海默氏病（AD）中海马磁共振成像（MRI）体积损失的程度通常被认为是疾病严重程度的标志，但仍然昂贵，无法获得或无法为许多患者所接受。目的：检查早期AD患者人群中一种或多种载脂蛋白E（ApoE）e4等位基因是否与较小的海马MRI量有关。方法：总共招募了88名在社区记忆障碍门诊就诊的患者，这些患者既患有临床痴呆症评定量表的轻度痴呆症，又患有可能患有AD的精神障碍诊断和统计手册标准。我们检查了MRI体积上的ApoE e4等位基因负荷与海马萎缩之间的关系。结果：在该队列中，ApoE e4负荷与海马体积之间没有关联。结论：这项研究表明，一个或多个ApoE e4等位基因的存在不能用于估计AD早期的病理疾病负荷。

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