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首页> 外文期刊>Revista de Gastroenterologia del Peru >Colorectal cancer in the young: clinicopathologic features and prognostic factors from a cancer institute in Peru
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Colorectal cancer in the young: clinicopathologic features and prognostic factors from a cancer institute in Peru

机译：年轻人的结直肠癌：秘鲁癌症研究所的临床病理特征和预后因素

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Objective: To determine clinicopathological features and prognostic factors among young colorectal cancer (CRC) patients in a Peruvian Cancer Institute. Methods: Data of patients 40 years or younger, admitted between January 2005 and December 2010, were analyzed. Results: During the study period, 196 young patients with CRC were admitted. The tumor was located in the rectum, left colon and right colon in 45.9%, 28.6% and 25.5% of cases. Family history of CRC was found in 13.2% and an autosomal pattern of inheritance, in 8.6% of the cases. The most common symptoms were pain (67.9%) and bleeding (67.3%). The majority (63.1%) of colon cancer cases and more than a third (34.4%) of rectal cancer cases were diagnosed in stage III or IV. The histologic type was tubular, mucinous and signet ring cell adenocarcinoma in 73.5%, 14.8% and 8.6%, respectively. The depth of invasion was T3 in 21.4% and T4 in 53%. Nodal involvement was detected in 44.5%. Five-year overall survival (OS) was 44.3%. In the multivariate analysis, only the stage resulted an independent prognostic factor for survival. Conclusions: CRC in Peruvian young patients is mostly sporadic. It presents more often in the distal colon or rectum and at advanced stages of the disease. Mucinous and signet ring cell carcinoma were frequent histological types. Five-year OS stage by stage is similar to that reported in the literature for older patients. Stage was the only independent prognostic factor for survival.
机译：目的：确定秘鲁癌症研究所的年轻结直肠癌（CRC）患者的临床病理特征和预后因素。方法：分析2005年1月至2010年12月期间收治的40岁及以下患者的数据。结果：在研究期间，收治了196例年轻的CRC患者。肿瘤分别位于直肠，左结肠和右结肠中，分别占45.9％，28.6％和25.5％。 CRC家族史占13.2％，常染色体遗传模式占8.6％。最常见的症状是疼痛（67.9％）和出血（67.3％）。大部分（63.1％）的结肠癌病例和超过三分之一（34.4％）的直肠癌病例被诊断为III或IV期。组织学类型分别为肾小管，粘液性和印戒细胞腺癌，分别为73.5％，14.8％和8.6％。浸润深度为T3为21.4％，T4为53％。检出淋巴结的比例为44.5％。五年总生存（OS）为44.3％。在多变量分析中，只有该阶段才得出生存的独立预后因素。结论：秘鲁年轻患者的CRC多数为散发性。它更常见于远端结肠或直肠以及疾病的晚期。粘液性和印戒细胞癌是常见的组织学类型。五年期OS分期与文献中报道的老年患者相似。分期是生存的唯一独立预后因素。

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