• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dental and Medical Problems >Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis
【24h】

Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis

机译：碳酸酐酶VI基因多态性对龋齿的影响：荟萃分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background . Carbonic anhydrase VI (CA VI) is considered to greatly participate in the buffering of saliva, ion transport, the regulation of pH, secretory processes, and saliva production. Various studies have been conducted to investigate the relationship between CA VI and dental caries. Objectives . The goal of this study was to make a meta-analysis of studies that examined the effects of the CA VI gene polymorphisms on dental caries. Material and Methods . The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guide was followed. Electronic databases (PubMed, Web of Science, Scopus, and Cochrane Library) were scanned by 2 independent researchers. The funnel plot, Egger’s regression and Begg and Mazumdar’s rank correlation test were used to determine publication bias. Cohen’s d was used to measure the effect size. Results . Four studies were included in the meta-analysis; a total of 3 polymorphisms (rs2274327, rs2274328, rs2274333) and a total of 13 polymorphism models were analyzed. According to Egger’s regression and the Begg and Mazumdar’s test, the meta-analysis had no significant publication bias (p 0.05). The highest susceptibility effect was noticed in the rs2274328 (AA vs CC) model (d = 0.18; 95% CI (confidence interval): ?1.77, 2.13), but this effect was not significant (p = 0.237), and the highest protective effect was observed in the rs2274328 (AA vs AC) model (d = ?0.13, 95% CI: ?1.36, 1.11), but this effect was not significant, either (p = 0.195). No association was found between any of the polymorphism models and dental caries (p 0.05). Conclusion . Even though CA VI plays an important role in the buffering of saliva, it was shown that polymorphisms in the CA VI gene did not affect the process of dental caries.
机译：背景 。碳酸酐酶VI（CA VI）被认为极大地参与了唾液的缓冲，离子运输，pH的调节，分泌过程和唾液的产生。已经进行了各种研究以调查CA VI和龋齿之间的关系。目标。这项研究的目的是对研究进行荟萃分析，以检查CA VI基因多态性对龋齿的影响。材料与方法 。遵循了《系统评价和荟萃分析的首选报告项目》（PRISMA）声明指南。电子数据库（PubMed，Web of Science，Scopus和Cochrane图书馆）由2位独立研究人员进行了扫描。使用漏斗图，Egger回归以及Begg和Mazumdar的秩相关检验确定发布偏差。 Cohen的d用于测量效果大小。结果。荟萃分析包括四项研究。总共分析了3个多态性（rs2274327，rs2274328，rs2274333）和总共13个多态性模型。根据Egger的回归以及Begg和Mazumdar的检验，荟萃分析没有明显的偏倚（p> 0.05）。在rs2274328模型（AA vs CC）中发现最高的药敏作用（d = 0.18; 95％CI（置信区间）：? 1.77，2.13），但这种作用不明显（p = 0.237），并且保护性最高。在rs2274328（AA与AC）模型中观察到了这种效应（d = ≤0.13，95％CI：≤1.36，1.11），但是这种效应也不显着（p = 0.195）。在任何多态性模型与龋齿之间均未发现关联（p> 0.05）。结论。尽管CA VI在唾液的缓冲中起着重要作用，但已证明CA VI基因的多态性不会影响龋齿的发生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号