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首页> 外文期刊>Dental and Medical Problems >Severe Pigmentation of Oral Mucosa, Skin and Nails Due to Breast Cancer Chemotherapy – Case Report
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Severe Pigmentation of Oral Mucosa, Skin and Nails Due to Breast Cancer Chemotherapy – Case Report

机译：乳腺癌化疗导致口腔粘膜，皮肤和指甲的严重色素沉着-病例报告

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Abstract Almost 10–20% of acquired melanocytic pigmentations are drug-induced in origin. Oral mucosa is a common place to develop drug reactions. In a 57-year-old Iranian female, severe pigmentation due to breast cancer chemotherapy with cyclophosphamide, 5-fluorouracil (5-FU) and doxorubicin was noticed during clinical examination. Extra-oral examination revealed linear dark bands on fingerand toenails as well as freckles on the face. Intraoral examination showed asymptomatic diffuse dark-brown pigmentation of the oral mucosa on the tongue, lips, palate, and buccal mucosa. The lesions were of poorly defined borders, various sizes and shape and a heterogeneous coloring to some extent. The tongue was more severely pigmented by dark gray to black patches. The patient was reassured about the etiology and nature of her problem and advised to return two months later. The lesions had almost disappeared by then. Awareness of chemotherapy complications is mandatory for physicians and dental practitioners to make accurate diagnoses.
机译：摘要获得性黑素细胞色素沉着的近10％至20％是由药物引起的。口腔粘膜是发生药物反应的常见场所。在一名57岁的伊朗女性中，在临床检查期间发现由于乳腺癌化疗中使用环磷酰胺，5-氟尿嘧啶（5-FU）和阿霉素引起的严重色素沉着。口外检查发现手指和脚趾甲上有线性暗带，脸上有雀斑。口内检查显示舌，唇，pa和颊粘膜无症状弥漫性暗褐色色素沉着。病变边界不清晰，大小和形状各异，并在一定程度上呈现出异质的颜色。舌头的色素沉着更为深灰色至黑色斑点。使患者对问题的病因和性质感到放心，并建议两个月后返回。到那时，病变几乎消失了。医师和牙科医生必须对化疗并发症有意识，才能做出准确的诊断。

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