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In vitro and in vivo analysis of the biodegradable behavior of a magnesium alloy for biomedical applications

机译:镁合金在生物医学领域的生物降解行为的体外和体内分析

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The present study was designed to investigate the biodegradation behavior of Mg alloy plates in the maxillofacial region. For in vitro analysis, the plates were immersed in saline solution and simulated body fluid. For in vivo , the plates were implanted into the tibia, head, back, abdominal cavity, and femur and assessed at 1, 2, and 4 weeks after implantation. After implantation, the plate volumes and the formed insoluble salt were measured via micro-computed tomography. SEM/EDX analysis of the insoluble salt and histological analysis of the surrounding tissues were performed. The volume loss of plates in the in vitro groups was higher than that in the in vivo groups. The volume loss was fastest in the abdomen, followed by the head, back, tibia, and femur. There were no statistically significant differences in the insoluble salt volume of the all implanted sites. The corrosion of the Mg alloy will be affected to the surrounding tissue responses. The material for the plate should be selected based on the characteristic that Mg alloys are decomposed relatively easily in the maxillofacial region.
机译:本研究旨在调查镁合金板在颌面部的生物降解行为。为了进行体外分析,将板浸入盐溶液和模拟的体液中。对于体内,将板植入胫骨,头部,背部,腹腔和股骨中,并在植入后1、2和4周进行评估。植入后,通过微型计算机断层摄影术测量板体积和形成的不溶性盐。进行了不溶性盐的SEM / EDX分析和周围组织的组织学分析。体外组中板的体积损失高于体内组中的板。腹部的体积减少最快,其次是头部,背部,胫骨和股骨。所有植入位点的不溶盐量均无统计学差异。镁合金的腐蚀会影响周围组织的反应。板的材料应根据镁合金在颌面区域相对容易分解的特性来选择。

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