• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dermato-Endocrinology >Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism
【24h】

Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism

机译：男性皮肤中类固醇代谢中与年龄和皮肤部位相关的差异表明皮脂细胞在皮肤激素代谢中的关键作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hormone concentrations decline with aging. Up to now it was not clear, whether the decrease of hormone concentrations in blood samples are also present in cutaneous suction blister fluids, and whether skin from different anatomical sites shows different hormone concentrations.Analysis of suction blister fluids and paired blood samples from young (mean 27.8 y) and old (mean 62.6 y) male subjects by UPLC-MS/MS showed that DHEA concentration in blood samples was age-dependently significantly reduced, but increased in suction blister fluids, while androstenedione behaved in an opposite manner to DHEA. Testosterone decreased age-dependently in blood samples and in suction blister fluids. Regarding skin sites, DHEA was lower in samples from upper back compared with samples from the forearm. In contrast, the concentrations of androstenedione and testosterone were higher in samples from upper back.In vitro analyses showed that SZ95 sebocytes, but neither primary fibroblasts nor keratinocytes, were able to use DHEA as precursor for testosterone biosynthesis, which was confirmed by expression analysis of 3β-hydroxysteroiddehydrogenase in skin biopsies.In conclusion, we show an inverse pattern of DHEA and androstenedione concentrations in blood vs. suction blister fluids, highlighting age-dependent changes of dermal testosterone biosynthesis, and a stronger metabolism in young skin. Furthermore, sebocytes play a central role in cutaneous androgen metabolism.
机译：激素浓度随衰老而下降。到目前为止，尚不清楚皮肤吸水疱液中是否也存在血液样本中激素浓度的降低，以及来自不同解剖部位的皮肤是否显示出不同的激素浓度。 UPLC-MS / MS的平均27.8岁）和老年（平均62.6岁）男性受试者显示，血液样本中的DHEA浓度显着降低，但在吸泡液中有所增加，而雄烯二酮的行为与DHEA相反。睾丸激素在血液样本和吸泡液中的年龄依赖性降低。关于皮肤部位，与前臂的样本相比，上背部样本的DHEA较低。相比之下，上背部样品中雄烯二酮和睾丸激素的浓度较高。体外分析显示SZ95皮脂细胞，但原代成纤维细胞和角质形成细胞均不能使用DHEA作为睾丸激素生物合成的前体，这通过皮肤活检中的3β-羟基类固醇脱氢酶。总的来说，我们发现血液与吸水泡状液中DHEA和雄烯二酮浓度呈反比关系，突显了皮肤睾丸激素生物合成的年龄依赖性变化以及年轻皮肤中更强的新陈代谢。此外，皮脂细胞在皮肤雄激素代谢中起重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号