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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >In vitro ?±- glucosidase inhibitory activities of ethonolic extract of Oldenlandia corymbosa
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In vitro ?±- glucosidase inhibitory activities of ethonolic extract of Oldenlandia corymbosa

机译：en木中乙醇提取物的体外α±葡萄糖苷酶抑制活性

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To evaluate the in vitro α- glucosidase inhibitory activities of ethanolic extract from aerial part of Oldenlandia corymbosa. Postprandial hyperglycemia which was focused in the therapy for diabetes was the prime characteristic of diabetes mellitus. Pancreatic α- glucosidase inhibitors techniques lower the levels of postprandial blood glucose levels by controlling carbohydrate metabolism and they are the most effective. The therapeutic methodologies includes diminishing hyperglycemia goes for inhibiting the enzyme α- glucosidase. Herbal remedies are well known for their establised ability and acceptability together with lower expenditure and lesser side effects for which they were considered more aporopriate for our study. The ethanolic extract obtained was subjected to in vitro alpha glycosidase inhibitory assay for which starch azure was used as the substrate and porcine pancreatic amylase as the enzyme . Enzyme solution was premixed with the extract at various concentrations (20, 40, 60, 80 and 100 mg/ml).Colorimetric reagents and Substrate solutions were added to the reaction. Spectrophotometric method was used to measure the release of glucose. The positive control used was acarbose. The extract (20 to 100 mg/ ml) was found to inhibit α- glucosidase activities. The extract has shown higher reduction of α-glucosidase. Inhibition at various concentrations were significantly different (p0.05).The results shows 90% reduction in α- glucosidase activity. This finding tells the utilization of ethanolic extract of aerial plant of Oldenlandia corymbosa is effective in inhibiting α-glucosidase thereby proving to be potential anti-diabeteic agent.
机译：为了评价Cohenmbosa陆地部分乙醇提取物的体外α-葡萄糖苷酶抑制活性。专注于糖尿病治疗的餐后高血糖症是糖尿病的主要特征。胰腺α-葡萄糖苷酶抑制剂技术通过控制碳水化合物的代谢来降低餐后血糖水平，是最有效的。治疗方法包括减少高血糖症以抑制酶α-葡萄糖苷酶。草药因其稳定的功能和可接受性以及较低的支出和较小的副作用而广为人知，因此被认为对我们的研究更合适。对所得乙醇提取物进行体外α-糖苷酶抑制试验，以淀粉天青为底物，猪胰淀粉酶为酶。将酶溶液与提取物以各种浓度（20、40、60、80和100 mg / ml）预混合。将比色试剂和底物溶液添加到反应中。用分光光度法测定葡萄糖的释放。使用的阳性对照是阿卡波糖。发现提取物（20至100 mg / ml）抑制α-葡萄糖苷酶活性。提取物显示出更高的α-葡萄糖苷酶还原率。各种浓度下的抑制作用均存在显着差异（p <0.05）。结果表明，α-葡萄糖苷酶活性降低了90％。该发现表明，利用Codenmbosa的陆地植物的乙醇提取物可有效抑制α-葡萄糖苷酶，从而被证明是潜在的抗糖尿病药。

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