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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >An Insight into Progress of Organic Motif Anti HIV Drug Discovery
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An Insight into Progress of Organic Motif Anti HIV Drug Discovery

机译：有机母体抗HIV药物发现进展的见解

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HIV, a dreadful virus has infected billions of people worldwide. It is spreading like anything despite the advances in the drug discovery. Even though innumerable strategies were designed most of them were in vain as the HIV virus has got inbuilt genetic mutation capability. Alongside, the virus is getting resistance to the chemical drugs. The chemical drugs are synthesized so as to target a particular protein of HIV which is most essential for its life. Few classes of drugs target the viruses in their latent stage and thereby reducing viral load. Some important classes of chemical drugs entail diarylpyrimidines, methoxy indoles and methoxy azoindoles etc. Some of the natural products are also derivatized to afford potent anti-HIV drugs. FDA (Food and Drug Administration) has approved a large number of drugs after clinical investigation under different phases. According to mode of their action, they have been classified as antifibrotics, CCR5 antagonists, integrase inhibitors, latency reversing agents, maturation inhibitors, (NNRTIs), (NRTIs), protease inhibitors, rev inhibitors, etc. Here in we reported the chemicals drugs synthesized from the past to present which includes a wide variety of synthetic chemical drugs possessing anti HIV potency. Also, the various drugs approved by the FDA were described.
机译：艾滋病毒是一种可怕的病毒，已经感染了全球数十亿人。尽管药物发现有所发展，它仍以任何形式传播。尽管设计了无数种策略，但大多数策略都是徒劳的，因为HIV病毒具有内置的基因突变能力。同时，病毒对化学药物也产生了抗药性。合成化学药物的目的是针对特定的HIV蛋白，该蛋白对其生命至关重要。很少有药物在潜伏期针对病毒，从而减少病毒载量。一些重要的化学药物类别包括二芳基嘧啶，甲氧基吲哚和甲氧基偶氮吲哚等。一些天然产物也被衍生化，以提供有效的抗HIV药物。经过不同阶段的临床研究，FDA（食品药品监督管理局）已经批准了多种药物。根据它们的作用方式，它们被分为抗纤维素，CCR5拮抗剂，整合酶抑制剂，潜伏期逆转剂，成熟抑制剂，（NNRTIs），（NRTIs），蛋白酶抑制剂，rev抑制剂等。在这里，我们报道了化学药物从过去到现在进行合成，包括具有抗HIV效力的多种合成化学药物。此外，还描述了FDA批准的各种药物。

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