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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Simultaneous Determination of Paracetamol, Lornoxicam and Chlorzoxazone in Tablets by High Performance Thin Layer Chromatography
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Simultaneous Determination of Paracetamol, Lornoxicam and Chlorzoxazone in Tablets by High Performance Thin Layer Chromatography

机译：高效薄层色谱法同时测定片剂中对乙酰氨基酚，氯诺昔康和氯唑沙宗

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摘要

A simple, specific, accurate and precise HPTLC method for simultaneous estimation of paracetamol, lornoxicam and chlorzoxazone as the bulk drug and in tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of chloroform: toluene: methanol: glacial acetic acid 6: 3: 1: 0.04 (v/v/v/v). Densitometric evaluation of the separated zones was performed at 275 nm. The three drugs were satisfactorily resolved with RF values 0.26 ± 0.02, 0.45 ± 0.03 and 0.53 ± 0.01 for paracetamol, lornoxicam and chlorzoxazone respectively. The method can be used for estimation of combination of these drugs in tablets. The method was validated as per ICH guidelines. The linearity of developed method was achieved in the range of 10 – 50 ng/spot for each of paracetamol, lornoxicam and chlorzoxazone and recoveries from tablets were between 99.27 ± 0.70, 99.37 ± 0.06 and 99.10 ± 0.30 %. Due to these attributes, the proposed method could be used for routine quality control analysis of these drugs in combined dosage forms.
机译：一种简单，特异，准确和精确的HPTLC方法，用于同时估算作为主要药物和片剂剂型的扑热息痛，氯诺昔康和氯唑沙宗。药物色谱分离是在预先涂有硅胶60 F254作为固定相的铝板上进行的，溶剂系统由氯仿：甲苯：甲醇：冰醋酸6：3：1：0.04（v / v / v / v ）。分离区域的光密度测定在275 nm进行。三种药物的对乙酰氨基酚，氯诺昔康和氯唑沙宗的RF值分别为0.26±0.02、0.45±0.03和0.53±0.01，令人满意。该方法可用于估计片剂中这些药物的组合。该方法已按照ICH指南进行了验证。对乙酰氨基酚，氯诺昔康和氯唑沙宗的开发方法线性均在10 – ng ng / s范围内，片剂的回收率在99.27±0.70、99.37±0.06和99.10±0.30％之间。由于这些属性，所提出的方法可以用于这些组合剂型药物的常规质量控制分析。

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