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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Chemicals/drugs-hepatotoxicants: An overview
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Chemicals/drugs-hepatotoxicants: An overview

机译：化学药品/药物-肝毒性：概述

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Hepatotoxicity is mainly caused by the inorganic compounds, organic agents and synthetic drugs. These inorganic compounds, organic agents and synthetic drugs which undergo metabolism in the liver and produces free radicals in the liver which causes liver damage. Drugs such as Statins, Methotrexate, Paracetamol, Alcohol etc are some common hepatotoxic agents. Approximately 75% of idiosyncratic drug reactions results in liver transplantation or death. These hepatotoxic drugs mainly increase the transaminase liver enzyme i.e. SGOT, SGPT and ALP level which is very much effective marker of liver disease. This review throws light on various drugs which induce hepatotoxicity with the overview of their common mechanism.
机译：肝毒性主要由无机化合物，有机试剂和合成药物引起。这些无机化合物，有机试剂和合成药物会在肝脏中进行代谢，并在肝脏中产生自由基，从而引起肝脏损害。他汀类药物，甲氨蝶呤，扑热息痛，酒精等药物是一些常见的肝毒性药物。大约75％的特异药物反应会导致肝移植或死亡。这些肝毒性药物主要增加转氨酶肝酶，即SGOT，SGPT和ALP水平，这是非常有效的肝病标志物。这篇综述着重介绍了各种诱导肝毒性的药物，并概述了它们的共同作用机理。

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