Synthesis of 3,5-diaryl-isoxazole-4-carbonitriles and their efficacy as antimicrobial agents

Vasanth Kumar Govindappa; Jayaroopa Prabhashankar; Bi Bi Ahmadi Khatoon; Mylarappa B Ningappa; Ajay Kumar Kariyappa

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Synthesis of 3,5-diaryl-isoxazole-4-carbonitriles and their efficacy as antimicrobial agents

机译：3,5-二芳基-异恶唑-4-腈的合成及其作为抗菌剂的功效

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Nitrile oxides generated in situ by the oxidative dehydrogenation of aromatic aldoximes (1a-g) undergo 1,3-dipolar cycloaddition reaction with 3-(4-methoxyphenyl)propiolonitrile (2) to afford the new cycloadducts 3-aryl-5-(4- methoxyphenyl)-isoxazole-4-carbonitriles (3a-g) in moderate yield. The new synthesized cycloadducts were tested for their antifungal and antibacterial activity.

机译：芳族醛肟（1a-g）的氧化脱氢原位生成的腈氧化物与3-（4-甲氧基苯基）丙腈（2）进行1,3-偶极环加成反应，得到新的环加合物3-芳基-5-（4 -甲氧基苯基）-异恶唑-4-腈（3a-g），产率中等。测试了新合成的环加合物的抗真菌和抗菌活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第6期|共5页
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Vasanth Kumar Govindappa; Jayaroopa Prabhashankar; Bi Bi Ahmadi Khatoon; Mylarappa B Ningappa; Ajay Kumar Kariyappa;
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中图分类化学;
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7. Synthesis of 3,5-diaryl-isoxazole-4-carbonitriles and their efficacy as antimicrobial agents. [O] . Govindappa V. K., Prabhashankar J., Khatoon B. A., 2012

机译：3,5-二芳基-异恶唑-4-腈的合成及其作为抗菌剂的功效。

Synthesis of 3,5-diaryl-isoxazole-4-carbonitriles and their efficacy as antimicrobial agents

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