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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Development and Validation of UV-Spectrophotometric methods for estimation of Indapamide in bulk and tablet dosage form
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Development and Validation of UV-Spectrophotometric methods for estimation of Indapamide in bulk and tablet dosage form

机译：紫外分光光度法测定散装和片剂剂型吲达帕胺的方法开发与验证

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摘要

Indapamide is an oral antihypertensive diuretic agent indicated for the treatment of hypertensive and edema [2]. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed two new, precise and simple UV spectrophotometric methods for estimation of Indapamide from bulk and tablet formulation in phosphate buffer 7.4. The drug obeyed the Beer’s law with correlation coefficient 0.996 and 0.998 respectively for Method I and Method II. It showed absorption maxima at 240 nm and 223 nm respectively for method I and Method II; in phosphate buffer 7.4. The linearity was observed between 5 –40 μg/ml. The results of analysis were validated by recovery studies, accuracy, precision, LOD, LOQ and ruggedness. The method was found to be simple, accurate, precise, economical and robust.
机译：吲达帕胺是口服降压利尿剂，可用于治疗高血压和水肿[2]。可以使用多种方法进行相同的分析，但是既费时又昂贵。在这里，我们开发了两种新的，精确的和简单的紫外分光光度法，用于从磷酸盐缓冲液7.4中的散装和片剂制剂中估算吲达帕胺。方法I和方法II的药物均符合比尔定律，相关系数分别为0.996和0.998。方法I和方法II分别显示了在240 nm和223 nm处的最大吸收值;在磷酸盐缓冲液7.4中。在5 – 40μg/ ml之间观察到线性。分析结果通过回收率研究，准确性，精密度，LOD，LOQ和耐用性进行了验证。发现该方法简单，准确，精确，经济且可靠。

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