Reactions of coumarin-3-carboxylate, its crystallographic study and antimicrobial activity

Jigar N. Soni; Shubhangi S. Soman

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Reactions of coumarin-3-carboxylate, its crystallographic study and antimicrobial activity

机译：香豆素-3-羧酸酯的反应，晶体学研究和抗菌活性

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Synthesis of various phenyl hydrazide derivatives have been carried out by reaction of various coumarin-3- carboxylate derivatives with phenyl hydrazine. The reaction of coumarin-3-carboxylate with hydrazine hydrate gave novel Schiff base products. The structures of these compounds have been confirmed by X-ray Single Crystal analysis. Mechanism for formation of Schiff base is proposed. All compounds were screened for antimicrobial activity against two Gram positive bacteria S. aureus and B. subtilis, two Gram negative bacteria E. coli and P. aeruginosa and one fungus C. albicans.

机译：通过各种香豆素-3-羧酸酯衍生物与苯基肼的反应已经进行了各种苯基酰肼衍生物的合成。香豆素-3-羧酸盐与水合肼的反应产生了新的席夫碱产物。这些化合物的结构已经通过X射线单晶分析确认。提出了席夫碱的形成机理。筛选所有化合物对两种革兰氏阳性细菌金黄色葡萄球菌和枯草芽孢杆菌，两种革兰氏阴性细菌大肠杆菌和铜绿假单胞菌以及一种真菌白色念珠菌的抗菌活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2014年第1期|共8页
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Jigar N. Soni; Shubhangi S. Soman;
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7. The bacterial identification and antimicrobial susceptibility testing are usually performed manually. Recently, the number of samples has increased and the need for automatification has grown. BioMerieux has investigated Vitek2 for this purpose. HUSLAB has assigned us to compare the identification and antimicrobial results with respect to routine methods and Vitek2. Furthermore, we evaluate test reactions, ESBL (Extended Spectrum Beta-Lactamase) production and the time what it takes to get results with Vitek2. In this study, we examined a total of 183 bacterial isolates including 76 ESBL-strains, 40 nonfermenting rods, 41 fastidious bacteria and 26 fresh clinical isolates. The results of routine methods were gathered from the patient database and following this, compared to the results given by Vitek2. Vitek2 correctly identified more than 96 f the ESBL-strains and fresh clinical isolates. The results of nonfermenting rods and fastidious bacteri a were 70 oncordant with those of the routine methods. Test reaction results of Api20E were 94 nd Api20NE 70 n concordance with Vitek2 results. Approximately 80 f all Vitek2 antimicrobial results and 90 f ESBL test results were correct. Compared to earlier studies, Vitek2 performed the tests faster than the routine methods. These results suggest that Vitek2 is capable of giving rapid and accurate results. However, nonfermenting rods and fastidious bacteria should be studied further. [O] . Järveläinen Marika, Roslund Iira, Silander Maarit 2006

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Reactions of coumarin-3-carboxylate, its crystallographic study and antimicrobial activity

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