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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Quantification of Ribavirin in Bulk and Pharmaceutical Preparation Using Spectrophotometry Technique
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Quantification of Ribavirin in Bulk and Pharmaceutical Preparation Using Spectrophotometry Technique

机译：分光光度法定量测定大剂量利巴韦林和药物制剂的含量

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摘要

Two simple, precise, accurate and sensitive visible spectrophotometric methods (I and II) have been established for quantifying ribavirin in pure form and pharmaceutical preparations. The proposed method I is based on the ability of ribavirin to reduce Folin-Ciocalteau reagent in alkaline medium to form a highly stable blue colored complex that can be measured spectrophotometrically at 760 nm. Method II is based on the formation of colored stable charge transfer complex, measured spectrophotometrically at 550 nm, between dichloro-5,6-dicyano-1,4- benzoquinone and ribavirin in acetonitrile medium. Variables affecting the chemical reaction were studied and optimized. The suggested methods I and II were validated as per ICH guidelines and successfully applied for quantification of the ribavirin in its pharmaceutical preparations like tablets, capsules and injections dosage forms with good accuracy and precision.
机译：已经建立了两种简单，精确，准确和灵敏的可见分光光度法（I和II）来定量纯形式和药物制剂中的利巴韦林。所提出的方法I基于利巴韦林在碱性介质中还原Folin-Ciocalteau试剂形成高度稳定的蓝色络合物的能力，可以在760 nm处用分光光度法进行测量。方法II是基于在乙腈介质中二氯5,6-二氰基-1,4-苯醌和利巴韦林之间在550 nm处分光光度法测定的有色稳定电荷转移络合物的形成。研究和优化了影响化学反应的变量。所建议的方法I和II已按照ICH指南进行了验证，并以良好的准确性和精确性成功应用于病毒制剂中的利巴韦林定量，如片剂，胶囊剂和注射剂。

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