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首页> 外文期刊>Dental and Medical Problems >Usage of Low Level Laser Biostimulation and Platelet Rich Fibrin in Bone Healing: Experimental Study
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Usage of Low Level Laser Biostimulation and Platelet Rich Fibrin in Bone Healing: Experimental Study

机译：低水平激光生物刺激和富血小板纤维蛋白在骨愈合中的应用：实验研究

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Abstract Background . Experimental studies have shown that low level laser therapy (LLLT) has a positive local biostimulative effect in the early stage of bone healing. Platelet rich fibrin (PRF) also has been shown to be effective in the treatment of intrabony periodontal defects. Objectives . The objective of our experimental study was to demonstrate the combined effects of LLLT and PRF on bone healing. Material and Methods . Our experimental study was done over 80 bony cavities in 20 adult male rabbits, aged 12 months. An incision was made for exposure of the femur bone of all rabbits. Then, by using a large, round surgical bur, a perforated hole was made in the femur. The cavities induced in these rabbits were divided into 4 groups: The control group which was neither subjected to any laser irradiation nor filled with any bone substitute (group I); The bony defects were filled with PRF (group II); The cavities were subjected to low level laser (LLL) for biostimulation (group III); The cavities were subjected to LLL for biostimulation then were filled with PRF (group IV). Histological assessments of the four groups were done using a hematoxylin and eosin stain. Statistical analysis was done using ANOVA and Bonferroni tests for comparisons between the four groups. Results . The area percentage of the newly formed bone in group IV was significantly higher than the other three groups. The area percentage of the newly formed bone in group III is significantly higher than group II. Conclusion . LLLT could induce bone formation in the bone defect at a faster rate than PRF. However, a combination of both LLLT and PRF as treatment modalities could induce bone formation in the bone defect more than that of LLLT or PRF alone.
机译：抽象背景。实验研究表明，低水平激光疗法（LLLT）在骨骼愈合的早期阶段具有积极的局部生物刺激作用。富含血小板的纤维蛋白（PRF）也已被证明可有效治疗骨内牙周缺损。目标。我们实验研究的目的是证明LLLT和PRF对骨愈合的综合作用。材料与方法 。我们的实验研究是在20个成年的12个月大的成年雄兔中进行的80多个骨腔的研究。切开切口以暴露所有兔的股骨。然后，通过使用大的圆形手术钻，在股骨上打一个穿孔。将这些兔子诱导的蛀牙分为四组：对照组，既不进行任何激光照射，也不填充任何骨替代物（I组）。骨缺损被PRF填充（第二组）;对腔进行低水平激光（LLL）进行生物刺激（第三组）;对腔进行LLL进行生物刺激，然后用PRF填充（IV组）。使用苏木精和曙红染色剂对四组进行组织学评估。使用ANOVA和Bonferroni检验对四组进行比较，进行统计分析。结果。 IV组中新形成的骨骼的面积百分比显着高于其他三组。第三组中新形成的骨头的面积百分比显着高于第二组。结论。 LLLT可以比PRF更快地诱导骨缺损中的骨形成。但是，将LLLT和PRF结合起来作为治疗方式比单独使用LLLT或PRF可以更多地诱导骨骼缺损中的骨形成。

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