...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >A Concise Comparative Mini Review between HPLC-UV and Spectrophotometric Analysis of Gliptins in Pharmaceutical Formulations
【24h】

A Concise Comparative Mini Review between HPLC-UV and Spectrophotometric Analysis of Gliptins in Pharmaceutical Formulations

机译：HPLC-UV和分光光度法分析药物制剂中脂蛋白的简要比较

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ongoing development of anti-diabetic drugs brings a revolution in the treatment of diabetes mellitus. Dipeptidyl Peptidase-4 (DPP-4) inhibitors are considered a new class of oral anti-diabetic agents used in treatment of type 2 diabetes mellitus. Therefore, the necessity to explore and compare the existing analytical method used for estimation of such drugs either single or in combination is crucial. This review offers an overview of different HPLC-UV and spectrophotometric methods used for determination of DPP-4 inhibitors namely; sitagliptin, vildagliptin, saxagliptin, linaglitpin and alogliptin in a tabulated comparative way. In addition, the present work included stability indicating assays of the drugs and determination of their process related impurities. Spectrophotometric assays showed more facilitated, simple and cost effective methods than the reported chromatographic techniques. Furthermore, the reviewed spectrophotometric methods showed the advantages of low cost solvents, shorter analysis time and simple instrumentation instead of complex details implemented in the chromatographic method development. The developed comparative review should be of interest to the analysts in the area of drug control and can be used by quality control laboratories for the recently approved gliptin combinations.
机译：抗糖尿病药的不断发展带来了糖尿病治疗方面的一场革命。二肽基肽酶-4（DPP-4）抑制剂被认为是用于治疗2型糖尿病的新型口服抗糖尿病药。因此，探索和比较用于评估此类药物（单一或组合）的现有分析方法的必要性至关重要。这篇综述概述了用于测定DPP-4抑制剂的不同HPLC-UV和分光光度法。西格列汀，维格列汀，沙格列汀，利拉利平和阿格列汀以列表比较方式列出。另外，目前的工作包括稳定性指示药的测定和与过程有关的杂质的测定。分光光度法显示比已报道的色谱技术更方便，更简单且更具成本效益的方法。此外，经过审查的分光光度法显示出低成本溶剂，缩短分析时间和简单仪器的优势，而不是色谱法开发中实现的复杂细节。分析员应该对药物控制领域的研究感兴趣，并且可以由质量控制实验室用于最近批准的格列汀组合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号