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首页> 外文期刊>Der Pharmacia Lettre >Formulation and in vitro evaluation of sustained releasemicrospheres of Metoprolol Tartrate Loaded Eudragit-RS100
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Formulation and in vitro evaluation of sustained releasemicrospheres of Metoprolol Tartrate Loaded Eudragit-RS100

机译：酒石酸美托洛尔缓释微球的制备及体外评价Eudragit-RS100

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摘要

The objective of the present study was to microencapsulate the Anti-Hypertensive drug (treatment of several disease of Cardio Vascular System, especially Hypertension.) Metoprolol Tartarte to provide Sustain Release and maintain constant the plasma drug concentration and reduce the frequent administration and improve the Patient compliance, unwanted side effects and Dose dumping. Metoprolol was microencapsulated with Eudragit-RS100 using solvent evaporation techniques. The effect of different 6 Formulation variables including the drug polymer ratio. Metoprolol Microspheres was subjected to micrometritic properties including Angle of Repose, Bulk density, Carra??s index, Haugnera??s ratio and Particle size determination. Metoprolol Microspheres was subjected to Drug Loading, invitro drug release as well as for Scanning electron microscope and kinetic drug release.
机译：本研究的目的是将抗高血压药微囊化（治疗几种心血管系统疾病，尤其是高血压）。美托洛尔酒石酸酯可提供缓释作用并保持血浆药物浓度恒定，减少频繁给药并改善患者病情顺应性，不良副作用和剂量倾倒。使用溶剂蒸发技术将美托洛尔与Eudragit-RS100微囊化。 6种不同配方变量（包括药物聚合物比例）的影响。对美托洛尔微球进行微观测量，包括休止角，堆积密度，Carra指数，Haugnera比率和粒度测定。对美托洛尔微球进行药物加载，体外药物释放以及扫描电子显微镜和动力学药物释放。

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