Anti-hyperglycemic evaluation of 2,4-thiazolidinedione and rhodanine derivatives

Archana Kapoor; Neha Khare

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Anti-hyperglycemic evaluation of 2,4-thiazolidinedione and rhodanine derivatives

【24h】

Anti-hyperglycemic evaluation of 2,4-thiazolidinedione and rhodanine derivatives

机译：2,4-噻唑烷二酮和若丹宁衍生物的抗高血糖评估

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A novel series comprising of 10 derivatives of two chemical entities thiazolidinedione and rhodanine were synthesized and characterized physicochemically as well as by spectral means. The synthesized derivatives (THP, RHP, RHB, MB01-MB09) were then screened for anti-hyperglycemic activity in fructose-induced diabetic animal model. It can be concluded that presence of piperazine and N-methyl piperazine at N-3 of thiazolidinedione and rhodanine derivatives have shown significant activity in comparison to aromatic amine substitution. The presence of ether linkage is the primary requisite for anti-hyperglycemic activity. Condensation of benzylidene with lipophilic moiety i.e. benzothiazole enhanced the activity of the synthesized derivatives. Piperazine substituted compound, MB01was most potent anti-hyperglycemic activity that might be due to the availability of free nitrogen at receptor site.

机译：合成了由两个化学实体的10个衍生物组成的新系列，其中噻唑烷二酮和若丹宁的理化性质以及通过光谱手段进行表征。然后在果糖诱导的糖尿病动物模型中筛选合成的衍生物（THP，RHP，RHB，MB01-MB09）的降血糖活性。可以得出结论，与芳族胺取代相比，噻唑烷二酮和若丹宁衍生物在N-3处存在哌嗪和N-甲基哌嗪已显示出显着的活性。醚键的存在是抗高血糖活性的首要条件。亚苄基与亲脂性部分即苯并噻唑的缩合提高了合成衍生物的活性。哌嗪取代的化合物MB01具有最强的抗高血糖活性，这可能是由于受体位点上的游离氮的有效性所致。

著录项

来源
《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2016年第12期|共12页
作者
Archana Kapoor; Neha Khare;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Antioxidant evaluation of 2,4-thiazolidinedione and rhodanine derivatives [J] . Archana Kapoor, Neha Khare Der Pharmacia Lettre . 2016,第14期

机译：2,4-噻唑烷二酮和若丹宁衍生物的抗氧化评价
2. Green synthesis of 5-arylidene-2,4-thiazolidinedione, 5-benzylidene rhodanine and dihydrothiophene derivatives catalyzed by hydrated ionic liquid tetrabutylammonium hydroxide in aqueous medium [J] . Ardeshir Khazaei, Hojat Veisi, Maryam Safaei Journal of sulfur chemistry . 2014,第1a6期

机译：水合离子液体氢氧化四丁基铵在水介质中绿色合成5-亚芳基-2,4-噻唑烷二酮，5-亚苄基罗丹宁和二氢噻吩衍生物
3. Catalyst-Free Synthesis of Highly Biologically Active 5-Arylidene Rhodanine and 2,4-Thiazolidinedione Derivatives Using Aldonitrones in Polyethylene Glycol [J] . DhruvaKumar, SureshNarwal, Jagir S.Sandhu International journal of medicinal chemistry. . 2013,第2期

机译：聚乙烯醇中醛基氮酮的无催化剂合成高生物活性5-亚芳基罗丹宁和2,4-噻唑烷二酮衍生物
4. Synthesis of new derivatives of Rhodanine dyes for Dye-Sensitized Solar Cells (DSSCs) [C] . BOUFARES Tahar, RAHMOUNI Mustapha, Mir-KASMI Souad Materials Science Technology Conference . 2015

机译：染料敏化太阳能电池罗达尼染料新衍生物的合成（DSSCs）
5. Design, synthesis, and pharmacological evaluations of potential anticonvulsant amino acid derivatives, carbamate compounds, and hexahydropyrimidine-2,4-diones. [D] . Kung, Ching-Hsin. 2002

机译：潜在的抗惊厥性氨基酸衍生物，氨基甲酸酯化合物和六氢嘧啶-2,4-二酮的设计，合成和药理评估。
6. Catalyst-Free Synthesis of Highly Biologically Active 5-Arylidene Rhodanine and 24-Thiazolidinedione Derivatives Using Aldonitrones in Polyethylene Glycol [O] . Dhruva Kumar, Suresh Narwal, Jagir S. Sandhu 2013

机译：在聚乙二醇中使用醛酮类无催化剂合成高生物活性的5-亚芳基罗丹宁和24-噻唑烷二酮衍生物
7. Síntese e atividade antiedematogênica de derivados N-triptofil-5-benzilideno-2,4-tiazolidinadiona e N-triptofil-5-benzilideno-rodanina Synthesis and antiedematogenic activity of some N-trypthophyl-5-benzylidene-2,4-thiazolidinedione and N-trypthophyl-5-benzylidene-rhodanine derivatives [O] . Alexandre José da Silva Góes, Waldir Tavares de Lima, Helena Juliana Nagy, 2004

机译：N-端基萘基-5-亚苄基-2,4-噻唑烷二酮衍生物和N-连呋喃基-5-亚苄基 - 罗丹宁的合成及抗生素活性一些N-端基萘基-5-亚苄基-2,4-噻唑烷二酮和N的合成及抗癫痫活性 - 对 - 萘基-5-亚苄基 - 若丹宁衍生物

Anti-hyperglycemic evaluation of 2,4-thiazolidinedione and rhodanine derivatives

摘要

著录项

相似文献

相关主题

期刊订阅