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首页> 外文期刊>Developmental Immunology: Journal of Immunology Research >Determinants of Vessel Targeting in Vasculitis
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Determinants of Vessel Targeting in Vasculitis

机译：血管炎中靶向血管的决定因素

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Studies of autoimmune diseases have not yet elucidated why certain organs or vessels become the objects of injury while others are spared. This paper will explore the hypothesis that important differences exist in regions of the aorta that determine vulnerability to diseases, such as atherosclerosis, aortitis, giant cell arteritis and Takayasu's disease. The reader is invited to reassess; (1) whether the aorta is indeed a single homogeneous structure, and (2) whether the initial stage of aortitis (and indeed other diseases considered “autoimmune”) may be primarily due to acquired alterations of substrate, that influence unique immune profiles, which by themselves may not be pathogenic. Disease susceptibility and patterns are influenced by many factors that are inborn and acquired. Examples include genetic background, gender, ethnicity, aging, prior and concomitant illnesses, habits, diet, toxin and environmental exposures. Studies of vascular diseases must assess how such variables may affect regional differences in endothelial cells, subendothelial matrix, vascular smooth muscle and the response of each to a variety of stimuli.
机译：自身免疫性疾病的研究尚未阐明为什么某些器官或血管成为受伤的对象，而另一些器官或血管却幸免了。本文将探讨以下假设：在主动脉区域中存在重要差异，这些差异决定了对疾病的脆弱性，例如动脉粥样硬化，主动脉炎，巨细胞动脉炎和Takayasu病。邀请读者重新评估; （1）主动脉是否确实是单一的同质结构，以及（2）主动脉炎的初始阶段（以及确实被认为是“自身免疫”的其他疾病）是否可能主要是由于获得性底物的改变而影响独特的免疫谱，本身可能不是致病的。疾病的易感性和模式受先天和后天的许多因素影响。例子包括遗传背景，性别，种族，衰老，先前和伴随的疾病，习惯，饮食，毒素和环境暴露。血管疾病的研究必须评估这些变量如何影响内皮细胞，内皮下基质，血管平滑肌的区域差异以及每种对多种刺激的反应。

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