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首页> 外文期刊>Developmental Immunology: Journal of Immunology Research >Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients
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Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients

机译：英夫利昔单抗诱导银屑病关节炎患者甘油三酸酯水平升高

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Objectives. To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA).Methods. Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included. None had dyslipoproteinemia or previous statin use. Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated.Results. The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8±49.7versus140.1±64.1 mg/dL,P=0.028) and VLDL-c (23.6±10.5versus28.4±13.7 mg/dL,P=0.019) levels. In contrast, there were no differences in the mean TC (P=0.28), LDL-c (P=0.42), and HDL-c (P=0.26) levels. Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05). Positive correlations were found between VLDL-c and CRP (r=0.647,P=0.009) and between triglycerides and CRP (r=0.604,P=0.017) levels at 3M. ESR reduction was observed after 3M (P=0.04). Mean prednisone dose remained stable at beginning and at 3M (P=0.37).Conclusion. This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months.
机译：目标。评估银屑病关节炎（PsA）患者抗TNF治疗后的脂质分布变化。纳入英夫利昔单抗治疗的15例PsA患者（8例多关节，4例少关节，2例轴向和1例残肢切除）。没有人有脂蛋白异常或他汀类药物使用。评估了总胆固醇（TC）及其分数，炎症标志物和泼尼松的使用。基线和抗TNF治疗三个月（3M）后血脂水平的比较显示，平均甘油三酸酯（117.8±49.7 vs140.1±64.1 mg / dL，P = 0.028）显着增加（23.6±10.5对28.4±13.7μg/ dL，P = 0.019）水平。相反，平均TC（P = 0.28），LDL-c（P = 0.42）和HDL-c（P = 0.26）水平没有差异。基线和3M时每个脂质改变的频率分析相似（P> 0.05）。在3M时，VLDL-c和CRP之间（r = 0.647，P = 0.009）以及甘油三酸酯和CRP水平（r = 0.604，P = 0.017）之间存在正相关。 3M后观察到ESR降低（P = 0.04）。平均泼尼松剂量在开始和3M时保持稳定（P = 0.37）。这项研究表明，三个月后，抗TNF可能会增加PsA患者的TG和VLDL-c水平。

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