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首页> 外文期刊>Dhaka University Journal of Pharmaceutical Sciences >Antinociceptive and Anthelmintic Activities of Leaves of Leea aequata
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Antinociceptive and Anthelmintic Activities of Leaves of Leea aequata

机译：赤木香叶片的抗伤害和驱虫活性

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摘要

The objective of the study was to evaluate the antinociceptive and anthelmintic activities of the crude methanol extract of leaves of Leea aequata and its fractions. The crude extract and its fractions at 200- and 400-mg/kg bw were subjected to assay for their antinociceptive activity using acetic acid induced writhing and radiant heat tail flicking methods. The ethyl acetate soluble fraction at 400 mg/kg bw induced 40.97% inhibition of writhing in mice while the carbon tetrachloride and chloroform soluble fractions of crude extract at the same dose displayed activity with 40.28% inhibition of writhing as compared to standard diclofenac sodium. The crude extract elongated the reaction time by 57.04% after 30 minute of administration in radiant heat tail flicking method, which suggested the central antinociceptive activity as compared to morphine. The methanol extract of the leaves of L. aequata exhibited profound anthelmintic activity in a dose dependent manner with shortest time of paralysis and death at 100 mg/ml concentration. It caused paralysis of the earthworm Pheretima posthuma at 9.44 min and death at 12.9 min when compared to the standard drug albendazole, which at 10 mg/ml concentration revealed the same at 8.21 minutes and 11.18 minutes, respectively.
机译：这项研究的目的是评估野木香叶片及其级分的粗甲醇提取物的抗伤害和驱虫活性。使用乙酸诱导的扭体法和辐射热甩尾法对粗提物及其馏分的200 mg / kg和400 mg / kg bw进行抗伤害感受活性测定。与标准双氯芬酸钠相比，400 mg / kg bw的乙酸乙酯可溶级分在小鼠中产生40.97％的扭体抑制作用，而粗提取物的四氯化碳和氯仿可溶级分在相同剂量下表现出活性，对扭体的抑制率为40.28％。在辐射热甩尾法中施用30分钟后，该粗提取物将反应时间延长了57.04％，这表明与吗啡相比，其中央镇痛活性。马鞭草叶片的甲醇提取物以剂量依赖的方式表现出强大的驱虫活性，在100 mg / ml的浓度下麻痹和死亡时间最短。与标准药物阿苯达唑相比，它在9.44分钟时导致hu Pheretima产后麻痹，在12.9分钟时导致死亡，后者在10 mg / ml浓度下分别在8.21分钟和11.18分钟时显示出相同的状态。

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