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首页> 外文期刊>Diabetologia: clinical and experimental diabetes and metabolism >γ-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study
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γ-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study

机译：γ-谷氨酰转移酶与肝纤维化的标志物无关，但与2型糖尿病老年人的心血管疾病有关：爱丁堡2型糖尿病研究

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Aims/hypothesis We examined the association of prevalent and incident cardiovascular disease (CVD) with chronic liver disease in a cohort of community-based people with type 2 diabetes, in order to clarify the relationship between these two important conditions. Methods 1,066 participants with type 2 diabetes aged 60–75 years underwent assessment of a range of liver injury markers (non-specific injury, steatosis, steatohepatitis, fibrosis, portal hypertension). Individuals were followed up for incident cardiovascular events. Results At baseline there were 370/1,033 patients with prevalent CVD, including 317/1,033 with coronary artery disease (CAD). After a mean follow-up of 4.4?years there were 44/663 incident CVD events, including 27/663 CAD events. There were 30/82 CVD-related deaths. Risk of dying from or developing CVD was no higher in participants with steatosis than in those without (HR 0.90; 95% CI 0.40, 2.00; p?>?0.05). The only notable relationship was with γ-glutamyltransferase (GGT) (incident CVD: adjusted HR for doubling GGT 1.24 [95% CI 0.97, 1.59] p?=?0.086; incident CAD: adjusted HR 1.33 [95% CI 1.00, 1.78] p?=?0.053), suggesting that in our study population, chronic liver disease may have little effect on the development of, or mortality from, CVD. Conclusions/interpretation An independent association between GGT and CVD warrants further exploration as a potentially useful addition to current cardiovascular risk prediction models in diabetes. However, overall findings failed to suggest that there is a clinical or pathophysiological association between chronic liver disease and CVD in elderly people with type 2 diabetes.
机译：目的/假设我们研究了一组以社区为基础的2型糖尿病患者的流行和突发心血管疾病（CVD）与慢性肝病的相关性，以阐明这两个重要疾病之间的关系。方法对1,066名60-75岁的2型糖尿病参与者进行了一系列肝损伤指标的评估（非特异性损伤，脂肪变性，脂肪性肝炎，纤维化，门脉高压）。对个体进行心血管事件的随访。结果基线时，有370 / 1,033名患有CVD的患者，其中317 / 1,033名患有冠心病（CAD）。在平均随访4.4年后，发生了44/663次CVD事件，包括27/663次CAD事件。有30/82与CVD相关的死亡。患有脂肪变性的参与者死于或发展为CVD的风险并不比没有肥胖者高（HR 0.90; 95％CI 0.40，2.00;p≥0.05）。唯一值得注意的关系是与γ-谷氨酰转移酶（GGT）（入射CVD：HR调整为GGT加倍1.24 [95 ％CI 0.97，1.59] p？=？0.086;入射CAD：HR调整为1.33 [95 ％CI 1.00， [1.78] p？=？0.053），这表明在我们的研究人群中，慢性肝病可能对CVD的发生或死亡几乎没有影响。结论/解释GGT和CVD之间的独立联系值得进一步探讨，因为它可能是当前糖尿病心血管风险预测模型的潜在有用补充。但是，总体研究结果未能表明在2型糖尿病老年人中，慢性肝病和CVD之间存在临床或病理生理联系。

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