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Carbon Dioxide Insufflation in Colonoscopy Is Safe: A Prospective Trial of 347 Patients

机译：结肠镜检查中的二氧化碳吹入是安全的：347例患者的前瞻性试验

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Available evidence suggests that the use of CO2insufflation in endoscopy is more comfortable for the patient. The safety of CO2use in colonoscopy remains contentious, particularly in sedated patients. The objective of the present prospective trial was to assess the safety of CO2colonoscopies.Methods. 109 patients from our previous randomized CO2colonoscopy study and an additional 238 subsequent consecutive unselected patients who had a routine colonoscopy performed in a private practice were enrolled from April 2008 through September 2008. All but 2 patients were sedated. All patients were routinely monitored with transcutaneous CO2measurement. Volumes of CO2administered were correlated with capnographic measurements from transcutaneous monitoring.Results. Of the 347 patients examined, 57% were women; mean (SD) age of participants was of 60.2 years (12.8). Mean propofol dosage was 136 mg (64 mg). Mean CO2values were 34.7 mm Hg (5.3) at baseline, 38.9 mm Hg (5.5) upon reaching the ileum, and 36.9 mm Hg (5.0) at examination's end. Mean maximum increase of CO2was 4.5 mm Hg (3.6). No correlation was observed between volume of CO2administered and increase in level of CO2(correlation coefficient: 0.01;Pvalue: 0.84). No complications were observed.Conclusions. The present prospective study, which was based on one of the largest sedated patient sample reported to date in this setting, provides compelling evidence that CO2insufflation in colonoscopy is safe and unassociated with relevant increases in transcutaneously measured levels of CO2.
机译：现有证据表明，在内窥镜检查中使用二氧化碳吹入对患者而言更为舒适。结肠镜检查中使用二氧化碳的安全性仍然存在争议，特别是在镇静患者中。本前瞻性试验的目的是评估CO2结肠镜检查的安全性。从2008年4月至2008年9月，我们纳入了109例来自我们先前的随机CO2结肠镜检查的患者，以及另外238例随后的连续非选择患者，这些患者在私人诊所进行了常规结肠镜检查。除2例患者均被镇静。所有患者均常规经皮二氧化碳监测。二氧化碳的施用量与经皮监测的二氧化碳图测量结果相关。在接受检查的347例患者中，女性占57％;参与者的平均（SD）年龄为60.2岁（12.8）。异丙酚的平均剂量为136毫克（64毫克）。基线时的平均CO2值为34.7 mm Hg（5.3），到达回肠后为38.9 mm Hg（5.5），检查结束时为36.9 mm Hg（5.0）。二氧化碳的平均最大增加量为4.5毫米汞柱（3.6）。施用CO 2的量与CO 2水平的增加之间没有相关性（相关系数：0.01; P值：0.84）。没有观察到并发症。结论。本前瞻性研究基于迄今为止在这种情况下报道的最大的镇静患者样本之一，提供了令人信服的证据，表明结肠镜检查中的二氧化碳注入是安全的，并且与经皮测量的二氧化碳水平的相关增加无关。

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