Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Ana Lúcia G.Demarco; Maria de Lourdes V.Rodrigues; José Fernando C.Figueiredo; Neifi Hassam S.Deghaide; Marcelo Bezerrade Menezes; Luís A.Demarco; Ana Paula M.Fernandes; Eduardo A.Donadi

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Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

机译：弓形体脉络膜脉络膜炎的易感性与Hla等位基因有关，据报道与Hla等位基因快速发展有关。

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Background/aims: The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).Methods: 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.Results: The HLA-B35 was significantly increased in TRC group (p= 0.0038).Conclusion: The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.

机译：背景/目的：在巴西患有或未患有弓形体脉络膜脉络膜炎（TRC）的艾滋病患者中评估了与快速发展为艾滋病相关的HLA标记的频率。方法：98例艾滋病患者（25例TRC，43例抗弓形虫抗体但结果：TRC组HLA-B35显着升高（p = 0.0038）。结论：HLA-B35的存在可能同时易患进展艾滋病和TRC。

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《Disease markers》 |2012年第6期|共4页
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Ana Lúcia G.Demarco; Maria de Lourdes V.Rodrigues; José Fernando C.Figueiredo; Neifi Hassam S.Deghaide; Marcelo Bezerrade Menezes; Luís A.Demarco; Ana Paula M.Fernandes; Eduardo A.Donadi;
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中图分类预防医学、卫生学;
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1. Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS [J] . Ana Lucia G. Demarco, Maria de Lourdes V. Rodrigues, Jose Ferno C. Figueiredo, Disease markers . 2012,第6期

机译：对弓形虫视网膜病变炎的易感性与报告的HLA等位基因有关，涉及助长艾滋病的快速进展
2. HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection. [J] . Gao X, OBrien TR, Welzel TM, AIDS . 2010,第12期

机译：HLA-B等位基因与HIV异性传播，病毒载量和发展为AIDS密切相关，但与易感性无关。
3. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). [J] . Deveau C, Guillemain H, Ratsimandresy R The Journal of Infectious Diseases . 2009,第8期

机译：快速发展队列的全基因组关联研究确定了艾滋病的新易感性等位基因（ANRS全基因组关联研究03）。
4. Involvement of hla alleles and haplotypes in susceptibility to age-related macular degeneration [C] . Gonzalez R., Villegas E., Manzanares B., European Congress of Immunology . 2009

机译：HLA等位基因和单倍型对年龄相关性黄斑变性的易感性
5. Attachment style and its correlation to rapidity of progression of AIDS in HIV-positive individuals. [D] . Weiss, Patti Jane. 1999

机译：依恋风格及其与艾滋病毒阳性患者艾滋病进展速度的关系。
6. Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids [O] . Ana Lúcia G. Demarco, Maria de Lourdes V. Rodrigues, José Fernando C. Figueiredo, 2012

机译：弓形虫性脉络膜脉络膜炎的易感性与Hla等位基因有关据报道与Hla等位基因快速发展有关。
7. HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection [O] . Xiaojiang Gao, Thomas R OBrien, Tania M Welzel, 2010

机译：HLA-B等位基因始终如一地与HIV异性透射，病毒载荷和进展促进，但不易感染
8. Rapid susceptibility testing of Mycobacterium avium complex and Mycobacterium tuberculosis isolated from AIDS patients [R] . Dhople, Arvind M. 1994

机译：从艾滋病患者分离的鸟分枝杆菌复合体和结核分枝杆菌的快速药敏试验

Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

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