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首页> 外文期刊>The Egyptian Journal of Hospital Medicine >The Prognostic Value of the Prechemotherapy Neutrophil - Lymphocyte Ratio in Gastric Cancer
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The Prognostic Value of the Prechemotherapy Neutrophil - Lymphocyte Ratio in Gastric Cancer

机译：胃癌化疗前中性粒细胞淋巴细胞比值的预后价值。

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Background: gastric cancer is the 5th most common cancer worldwide, with about one million newly diagnosed cases annually. It causes one of the highest cancer burdens, as measured by disability-adjusted life years lost. It is the third-leading cause of cancer-related death worldwide, after lung and liver malignancies. It is increasingly recognized that variations within clinical outcomes in cancer patients are influenced by not only the oncological characteristics of the tumor, but also the host-response factors. Aim of the work: this study aimed to investigate the prognostic value of prechemotherapy NLR in the gastric cancer patients and also to assess the association between high NLR and clinicopathological features; e.g. tumor stage, site, gross morphology ...etc. Patients and methods: this retrospective study included patients, diagnosed with gastric or gastroesophageal cancer, who presented to Oncology Department in Ain Shams University Hospital from January 2013 till December 2016. 61 patients were included in this study. Results: we found a significant correlation between presence of ascites and high NLR. This relation wasn't discussed in any previous study as far as we know. There was a significant correlation between NLR and each of the following: - overall survival and event-free survival. This was consistent with the results of previous studies worldwide. Therefore, our study proved that the prechemotherapy NLR is a prognostic factor in gastric cancer. Conclusion: the prechemotherapy NLR was significantly correlated with presence of ascites at diagnosis of gastric cancer. It is an independent prognostic factor in gastric cancer. It affects both event free survival and overall survival.
机译：背景：胃癌是全球第五大最常见的癌症，每年约有一百万例新诊断病例。按照失去的残疾调整生命年来衡量，它导致了最高的癌症负担之一。它是继肺癌和肝癌之后全球第三大与癌症相关的死亡原因。越来越多地认识到，癌症患者临床预后内的变化不仅受肿瘤的肿瘤学特征的影响，而且还受宿主反应因素的影响。工作目的：本研究旨在探讨化疗前NLR在胃癌患者中的预后价值，并评估高NLR与临床病理特征之间的关联;例如肿瘤分期，部位，总体形态等患者和方法：这项回顾性研究包括2013年1月至2016年12月在Ain Shams大学医院肿瘤科就诊的确诊为胃癌或胃食管癌的患者。该研究包括61名患者。结果：我们发现腹水的存在与高NLR之间存在显着相关性。据我们所知，以前的任何研究都没有讨论这种关系。 NLR与以下各项之间存在显着相关性：-总体生存率和无事件生存率。这与之前的全球研究结果一致。因此，我们的研究证明了化疗前NLR是胃癌的预后因素。结论：在胃癌的诊断中，化疗前的NLR与腹水的存在密切相关。它是胃癌的独立预后因素。它影响无事件生存和整体生存。

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