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首页> 外文期刊>The Egyptian Journal of Hospital Medicine >Role of folic acid deficiency as a possible risk factor for erectile dysfunction
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Role of folic acid deficiency as a possible risk factor for erectile dysfunction

机译：叶酸缺乏可能是勃起功能障碍的危险因素

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Background: erectile dysfunction (ED) is the persistent inability to attain or maintain an erection. ED affects millions of men worldwide. The pathophysiology of ED includes vasculogenic, neurogenic, hormonal, anatomical, drug-induced and psychogenic causes. Endothelial dysfunction (EDys) is an important pathophysiologic factor underlying vasculogenic erectile dysfunction. The pathogenesis of both EDys and ED are linked through decreased expression and activation of endothelial nitric oxide synthase (NOS) which is responsible for formation of Nitric Oxide (NO). NO is a relaxing factor which plays a major role in activation and maintenance of the erection process. Aim of the work: this study aimed to detect the possible relationship between serum folic acid and erectile dysfunction by measuring serum FA concentration in patients with erectile dysfunction and comparing them with the healthy controls. Methodology: our study has been carried out on 90 individuals who were categorized into two groups. Group 1: 60 married males complained of ED. Group 2: 30 married potent males as a control.All participants were subjected to : personal history, past history of medical diseases and operations, sexual history, general examination, genital examination and evaluation of erectile function according to the International Index of Erectile Function (IIEF-5) Questionnaire). Fasting serum samples were collected from all participants and assayed for serum total testosterone, serum prolactin, serum cholesterol, serum triglycerides (TG), HbA1c and serum folic acid. Results: results of the current study showed a significant relation between folic acid and ED. FA level was declined as ED severity increased. It is thought that ED severity was related to HHcy which was related to the severity of FA deficiency. Conclusion: a significant association between serum FA level and ED severity was detected in the current study. Serum FA level decreased as the severity of ED increased. These results suggest that FA deficiency might reflect the severity of ED. Recommendations: serum folic acid assessment as a part of the routine investigations for patients complaining with erectile dysfunction. Additional experimental and clinical studies are needed to determine whether FA supplementation may be beneficial for patients having ED.
机译：背景：勃起功能障碍（ED）是持续无法实现或维持勃起的功能。 ED影响全球数百万男人。 ED的病理生理学包括血管生成，神经生成，激素，解剖，药物诱发和心理原因。内皮功能障碍（EDys）是潜在的血管生成性勃起功能障碍的重要病理生理因素。 EDys和ED的发病机制通过减少内皮一氧化氮合酶（NOS）的表达和激活而联系起来，而内皮一氧化氮合酶负责形成一氧化氮（NO）。 NO是一种放松因素，在激活和维持勃起过程中起着重要作用。工作目的：本研究旨在通过测量勃起功能障碍患者的血清FA浓度并将其与健康对照进行比较，以检测血清叶酸与勃起功能障碍之间的可能关系。方法：我们的研究针对90位被分为两组的个体进行。第一组：60名已婚男性抱怨ED。第2组：以30名已婚有力男性为对照，所有参与者均接受以下检查：个人病史，既往医疗史和手术史，性病史，一般检查，生殖器检查以及根据国际勃起功能指数评估勃起功能IIEF-5）问卷。从所有参与者中收集空腹血清样品，并进行血清总睾丸激素，血清催乳素，血清胆固醇，血清甘油三酸酯（TG），HbA1c和血清叶酸的测定。结果：目前的研究结果表明叶酸和ED之间存在显着关系。随着ED严重程度的增加，FA水平下降。认为ED的严重程度与HHcy有关，而HHcy与FA缺乏的严重程度有关。结论：在本研究中发现血清FA水平与ED严重程度之间存在显着关联。血清FA水平随着ED严重程度的升高而降低。这些结果表明，FA缺乏可能反映了ED的严重程度。建议：血清叶酸评估应作为抱​​怨勃起功能障碍患者常规检查的一部分。还需要进行其他实验和临床研究，以确定补充FA对患有ED的患者是否有益。

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