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首页> 外文期刊>The Egyptian Journal of Hospital Medicine >Evaluation of Serum Interferon-gamma Level in Vitiligo Patients
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Evaluation of Serum Interferon-gamma Level in Vitiligo Patients

机译：白癜风患者血清γ-干扰素水平的评估

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Background: Vitiligo is an acquired depigmentation disorder of the skin, resulting from a loss of functioning epidermal melanocytes. Multiple pathogenetic factors have been proposed, including the neural theory, genetic predisposition and impaired anti-oxidative defense. Cytokines are small immune- regulatory molecules that can generate an inappropriate immune response when imbalanced. IFN- is a pleiotropic cytokine that is a key regulator of the immune system. In addition to host defense, IFN- also contributes to autoimmune pathology by inducing autoantibodies, activating autologous cytotoxic T cells and inducing target cell apoptosis. It plays an important role to induce depigmentation in vitiligo. Aim: In this study, we aimed to determine whether vitiligo is associated with alterations in serum level of IFN- or not and to find out its association with disease course, severity, and duration. Methods: This case control study included 40 patients presented with stable (N=22) and active (N=18) vitiligo (non-segmental and segmental), diagnosed on the basis of typical clinical features, were selected as patient group. Forty age and sex matched apparently healthy individuals were also included representing the control group. Also patients with previous skin cancer or premalignant skin lesions, or taking immunosuppressive drugs as methotrexate and patients with hepatitis viral infection and those on INF therapy were excluded. They were 25 females (62.5%) and 15 males (37.5 %), their ages ranged from 18 to 45 years old (mean of 33.53). The controls were 20 females (50%) and 20 males (50%), their ages ranged from 18 to 46 years old (mean of 32.85). Results: The distribution of vitiligo in patients, 60% was vitiligo vulgaris, 25% were segmental vitiligo and 15% were acro-fascial vitiligo. The results showed no statistical significant difference (p-value 0.05) between patients and control as regard age, sex and family history and showed statistical significant difference (p-value 0.001) between patients and control as regard serum concentration of IFN-. Results also showed statistical significant (p-value 0.001) positive (r = 0.63) correlation between IFN- levels and VASI score in patients group and statistical significant difference (p-value 0.001) between IFN- levels and duration, clinical types and activity of the disease in patients group. Conclusion: This study proved high serum level of IFN- may be risk factor for vitiligo progression suggesting that it could be used as a marker for assessing vitiligo activity and may open the way for further therapeutic approaches for vitiligo. Serum IFN- is positively correlated with disease duration and severity, although it does not seem to be influenced by age, sex and family history of the patient.
机译：背景：白癜风是由于功能性表皮黑素细胞丧失导致的一种获得性皮肤脱色素病。已经提出了多种致病因素，包括神经理论，遗传易感性和抗氧化防御能力受损。细胞因子是小的免疫调节分子，当失衡时会产生不适当的免疫反应。 IFN-是一种多效细胞因子，是免疫系统的关键调节因子。除了宿主防御外，IFN-α还通过诱导自身抗体，激活自体细胞毒性T细胞和诱导靶细胞凋亡来促进自身免疫病理。它在诱发白癜风的色素沉着中起重要作用。目的：在这项研究中，我们旨在确定白癜风是否与血清IFN-水平的改变有关，并找出其与疾病进程，严重程度和持续时间的关系。方法：本病例对照研究包括40例表现稳定（N = 22）和活动性（N = 18）白癜风（非节段性和节段性）的患者，根据典型临床特征进行诊断，将其作为患者组。包括40个年龄和性别相匹配的显然健康的个体也代表对照组。此外，既往曾患有皮肤癌或癌前病变的患者，或服用免疫抑制药物作为甲氨蝶呤的患者，肝炎病毒感染的患者以及接受INF治疗的患者也被排除在外。他们是25名女性（62.5％）和15名男性（37.5％），年龄在18至45岁之间（平均33.53）。对照组为20位女性（50％）和20位男性（50％），年龄范围为18至46岁（平均32.85）。结果：患者白癜风分布，寻常型白癜风60％，节段性白癜风25％，顶筋膜白癜风15％。结果表明，就年龄，性别和家族史而言，患者与对照组之间无统计学差异（p值> 0.05），而血清与IFN-的浓度之间无统计学意义（p值<0.001）。结果还显示患者组中IFN-水平与VASI评分之间的统计学显着性（p值<0.001）（r = 0.63）呈正相关（r = 0.63），IFN-α水平与病程，临床类型和持续时间之间的统计学显着性差异（p值<0.001）。患者组疾病的活动。结论：这项研究证明血清高水平的IFN-α可能是白癜风进展的危险因素，表明它可以用作评估白癜风活性的标志物，并可能为进一步治疗白癜风的方法开辟道路。血清IFN-γ与疾病的持续时间和严重程度呈正相关，尽管它似乎不受患者的年龄，性别和家族史的影响。

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