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首页> 外文期刊>Disease markers >Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages
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Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages

机译：白细胞介素34滑液与膝骨性关节炎的严重程度有关：膝关节骨性关节炎患者在不同射线照相阶段的横断面研究

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Background. Inflammation might play a crucial role in the pathogenesis of osteoarthritis (OA). Interleukin-34 (IL-34) is a well-known proinflammatory cytokine. Objective. The objective of this study was to detect IL-34 levels in serum and synovial fluid (SF) of patients with OA and to investigate their correlation with radiographic and symptomatic severity. Methods. One hundred and eighty-two OA patients and 69 controls were recruited. IL-34 levels were measured by enzyme-linked immunosorbent assay (ELISA). Radiographic and symptomatic severity of OA was reflected by Kellgren-Lawrence (KL) grades and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores, respectively. Results. SF IL-34 levels were independently associated with the KL grade (, 95% CI 0.150–0.395; ). SF IL-34 levels were significantly correlated with WOMAC scores (, 95% CI 0.123–0.399; ). The correlation between SF IL-34 levels and WOMAC scores was still significant after adjusting for confounding factors (, 95% CI 0.001–0.038; ) in OA patients. Conclusions. We found that IL-34 levels in SF were significantly associated with the radiographic and symptomatic severity of knee OA.
机译：背景。炎症可能在骨关节炎（OA）的发病机理中起关键作用。白介素34（IL-34）是众所周知的促炎细胞因子。目的。这项研究的目的是检测OA患者血清和滑液（SF）中的IL-34水平，并研究它们与影像学和症状严重程度的相关性。方法。招募了182名OA患者和69名对照。通过酶联免疫吸附测定（ELISA）测量IL-34水平。 OA的放射学和症状严重程度分别由Kellgren-Lawrence（KL）评分和西安大略麦克马斯特大学骨关节炎指数（WOMAC）评分反映。结果。 SF IL-34水平与KL等级独立相关（95％CI 0.150-0.395;）。 SF IL-34水平与WOMAC评分显着相关（95％CI 0.123–0.399;）。校正OA患者的混杂因素（95％CI 0.001–0.038;）后，SF IL-34水平与WOMAC评分之间的相关性仍然很显着。结论。我们发现SF中的IL-34水平与膝OA的影像学和症状严重程度显着相关。

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