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首页> 外文期刊>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery >Could P300 Predict Remission in Patients with Schizophrenia?
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Could P300 Predict Remission in Patients with Schizophrenia?

机译：P300可以预测精神分裂症患者的缓解吗？

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Background: Schizophrenia is nowadays viewed as a general cognitive disorder characterized by relatively stable cognitive impairments. Event-related potentials offer an approach for eliciting neurophysiological correlates of cognitive functioning. The P300 event-related brain potential (ERP) is an index of endogenous cognitive processes. Objective: This study sought to determine whether P300 can indicate the change in cognitive functions in schizophrenic patients and to evaluate its value in predicting remission. Methods: We studied 93 schizophrenic patients and 30 controls over 2 years. The age, gender, marital status, level of education and occupation were analyzed. Patients were assessed by the following scales: scales for assessment of positive and negative symptoms (SAPS and SANS) of schizophrenia and Wechsler Memory scale (WMS). Neurophysiological assessment with Event-related potentials (P300) was done for patients and control groups. Patients were maintained on antipsychotics whether typical or atypical, followed regularly twice per month over 6 months and they were reassessed with the same tools of assessment. Results: A total of 93 patients were studied; they were 60 males and 33 females with a mean age of 22.56±7.07 years. There was a significant difference between patients and control as regard all P300 variables. Treatment with antipsychotics led to variable degree of improvement in most cognitive scales. P300 amplitude was the only P300 variable which showed improvement with antipsychotics. On doing regression analysis, significant correlation (R2=0.599, F=55.05) was found between P300 amplitude and positive symptoms (SAPS). Conclusion: P300 is a useful tool for assessing cognitive functions and predicting remission in schizophrenic patients. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(3): 241-246]
机译：背景：精神分裂症如今被认为是一种以相对稳定的认知障碍为特征的一般性认知障碍。事件相关电位提供了一种引发认知功能的神经生理相关性的方法。 P300事件相关的脑电势（ERP）是内源性认知过程的指标。目的：本研究旨在确定P300是否可以指示精神分裂症患者认知功能的变化，并评估其在预测缓解中的价值。方法：我们研究了93名精神分裂症患者和30名对照者，历时2年。分析了年龄，性别，婚姻状况，受教育程度和职业。通过以下量表对患者进行评估：精神分裂症阳性和阴性症状的评估量表（SAPS和SANS）和韦氏记忆量表（WMS）。对患者和对照组进行了具有事件相关电位（P300）的神经生理学评估。对患者进行抗精神病药物治疗（无论是典型的还是非典型的），并在6个月内每月定期进行两次随访，并使用相同的评估工具对其进行重新评估。结果：共研究了93例患者。他们是男性60例，女性33例，平均年龄为22.56±7.07岁。在所有P300变量方面，患者与对照组之间存在显着差异。抗精神病药治疗导致大多数认知量表的改善程度有所不同。 P300幅度是唯一显示抗精神病药改善的P300变量。在进行回归分析时，发现P300振幅与阳性症状（SAPS）之间存在显着相关性（R2 = 0.599，F = 55.05）。结论：P300是评估精神分裂症患者认知功能和预测缓解的有用工具。 [埃及J Neurol精神病神经外科。 2011; 48（3）：241-246]

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