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首页> 外文期刊>The Egyptian Journal of Neurology, Psychiatry and Neurosurgery >Memory and Attention Impairment after Traumatic Brain Injury
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Memory and Attention Impairment after Traumatic Brain Injury

机译：脑外伤后的记忆力和注意力障碍

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Background: Deficits in memory and attention have been reported following traumatic brain injury (TBI) and there is evidence that the cholinergic system is frequently involved in these cognitive consequences. Objective: To study the effect of moderate to severe TBI on the cognitive functions facilitated by the cholinergic system.  Methods: The data of 25 patients with history of TBI on admission was reviewed including: Glasgow coma scale (GCS), Marshall Score, and the number of days of admission in ICU. During the follow up visit after 6 months of the trauma, all patients underwent neurological examination including mini mental state examination (MMSE) and Glasgow outcome scale (GOS). Neuropsychological assessment was done by using Cambridge Neuropsychological Test Automated Battery (CANTAB). Results: The median GCS on admission was eight. The surviving population at 6 months consisted of two (8%) patients with GOS of 3, 10 (40%) with GOS of 4 and 13(52%) with GOS of 5. There was a significant difference between the groups on the MMSE score, although both groups were within the normal range.  Performance on the CANTAB showed that spatial span, spatial working memory and set shifting did not differ between the two groups. On the other hand, there was a significant difference on rapid visual information processing, pattern and spatial recognition, reaction time and paired associate learning. Conclusion: These cognitive results are consistent with cholinergic dysfunction. The cholinergic enhancers may be considered helpful in the treatment of cognitive deficits after TBI. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(2): 143-148]
机译：背景：脑外伤（TBI）后已有记忆和注意力不足的报道，并且有证据表明胆碱能系统经常参与这些认知后果。目的：研究中度至重度TBI对胆碱能系统促进的认知功能的影响。方法：回顾了25例TBI病史患者的入院数据，包括：格拉斯哥昏迷量表（GCS），马歇尔评分和ICU入院天数。在创伤六个月后的随访中，所有患者均接受了神经系统检查，包括迷你精神状态检查（MMSE）和格拉斯哥预后量表（GOS）。通过使用剑桥神经心理测试自动电池（CANTAB）进行神经心理评估。结果：入院时的GCS中位数为8。在6个月时，幸存的人群包括2（8％）的GOS为3的患者，10（40％）的GOS为4的患者和13（52％）的GOS为5的患者。得分，尽管两组均在正常范围内。 CANTAB上的性能表明，两组之间的空间跨度，空间工作记忆和集合移位没有差异。另一方面，在快速视觉信息处理，模式和空间识别，反应时间和配对联想学习方面存在显着差异。结论：这些认知结果与胆碱能功能障碍一致。胆碱能增强剂可能被认为有助于TBI后认知功能障碍的治疗。 [埃及J Neurol精神病神经外科。 2013; 50（2）：143-148]

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