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首页> 外文期刊>Drug Design, Development and Therapy >Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China
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Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China

机译：脉冲染料激光处理葡萄酒色斑的回顾性研究：中华人民共和国山东省848例

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Background: Currently, 595 nm pulsed dye laser (PDL) therapy is offered as one of the effective treatments of port wine stains (PWSs). However, the efficacy of PDL differs in different populations.Objective: The purpose of the study was to investigate the efficacy, and related factors, of 595 nm PDL in the treatment of PWSs in Chinese patients with skin type III to IV. Methods: A total of 848 cases that were treated with PDL were enrolled and analyzed in this study. An independent dermatologist evaluated these lesions according to the before and after photographs.Results: The response rate (RR) of all the 848 PWS patients was 69.9%, within which the cure rate was 6.3%. The patients aged ≤1 year had the highest RR (93.9%), whereas those treated after age 50 reacted the worst (RR =25%). We analyzed the anatomical distribution of the lesion and found that the temporal region had the highest lesion clearance (RR =75.3%), while the extremities had the lowest clearance (RR =44.5%). Compared with the patients whose lesion size was larger than 80 cm2, the patients with small lesion size, of 0–20 cm2, had better clinical effect (RR =73.8% vs 53.2%). The reactions of the patients with hyperplastic lesion were worse than those with red patches (RR =36.4% vs 71.7%). As well, increasing treatment numbers could achieve higher clearance rates (P=0.005).Conclusion: The PDL had a relatively high RR but a low clearance rate in Chinese patients with PWS, although the earlier the intervention, the better was the efficacy. The response of PDL was, not only related to the anatomical area, but also, to the lesion size, type?of lesion (ie, the presence of existing hyperplastic lesions), and the number of treatment, all of which are essential for the evaluation of therapeutic effect and acquisition of patients consent before treatment.
机译：背景：目前，提供595 nm脉冲染料激光（PDL）治疗作为波特酒渍（PWSs）的有效治疗方法之一。然而，不同人群的PDL疗效不同。目的：研究595 nm PDL在中国III至IV型皮肤病患者中治疗PWS的疗效及相关因素。方法：本研究共入选848例接受PDL治疗的患者。结果：848例PWS患者的缓解率（RR）为69.9％，其中治愈率为6.3％。 ≤1岁的患者的RR最高（93.9％），而50岁以后接受治疗的患者的反应最差（RR = 25％）。我们分析了病变的解剖分布，发现颞部的病变清除率最高（RR = 75.3％），而四肢的病变清除率最低（RR = 44.5％）。与病变大小大于80 cm2的患者相比，病变大小为0–20 cm2的患者具有更好的临床效果（RR = 73.8％vs 53.2％）。增生性病变患者的反应比红色斑块的患者差（RR = 36.4％vs 71.7％）。同样，增加治疗次数可以达到更高的清除率（P = 0.005）。结论：PDL在中国PWS患者中具有较高的RR，但清除率较低，尽管干预越早，疗效越好。 PDL的反应不仅与解剖区域有关，而且与病变的大小，病变的类型（即是否存在增生性病变）和治疗的数量有关，所有这些对于PDL都是必不可少的。评估治疗效果并获得治疗前患者的同意。

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